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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P36956
No. Gene UniProt ID Protein Name Pathway PDB
1 SREBF1 P36956 Sterol regulatory element-binding protein 1 hsa04152; hsa04910; hsa04931; hsa04932 1AM9


3 known interactions (drugs) of input target (SREBF1): Sterol regulatory element-binding protein 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB11133 Omega-3 fatty acids Thumb
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb


20 predicted interactions (drugs) of input target (SREBF1): Sterol regulatory element-binding protein 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 30.8%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 30.6%
3 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb 29.0%
4 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 29.0%
5 Approved;
Experimental		 SmallMoleculeDrug DB03796 Palmitic Acid Thumb 28.3%
6 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 27.9%
7 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb 27.5%
8 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 27.2%
9 Approved;
Investigational		 SmallMoleculeDrug DB00328 Indomethacin Thumb 27.0%
10 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb 26.8%
11 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 26.5%
12 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 26.3%
13 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 26.0%
14 Investigational SmallMoleculeDrug DB06536 Tesaglitazar Thumb 25.1%
15 Approved SmallMoleculeDrug DB00573 Fenoprofen Thumb 25.1%
16 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 25.0%
17 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 23.8%
18 Approved;
Investigational		 SmallMoleculeDrug DB12007 Isoflavone Thumb 23.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB01132 Pioglitazone Thumb 23.3%
20 Experimental SmallMoleculeDrug DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Thumb 22.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.