QuartataWeb 1.0

30 known interactions (drugs) of input target (NCOA2): Nuclear receptor coactivator 2

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Experimental	SmallMoleculeDrug	DB08595	4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	[H][C@]12CC=C(C)[C@]([H])(C1)[C@@]([H])(OC2(C)C)C1=CC=C(O)C=C1
2	Approved; Investigational	SmallMoleculeDrug	DB00255	Diethylstilbestrol	CCC(=C(CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
3	Experimental	SmallMoleculeDrug	DB08773	RALOXIFENE CORE	OC1=CC=C(C=C1)C1=CC2=C(S1)C=C(O)C=C2
4	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB13954	Estradiol cypionate	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@]12C)OC(=O)CCC1CCCC1
5	Experimental	SmallMoleculeDrug	DB08320	DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE	[H][C@]12O[C@]([H])(C(=C1C1=CC=C(O)C=C1)C1=CC=C(O)C=C1)[C@]([H])(C(=O)OCC)[C@]2([H])C(=O)OCC
6	Investigational	SmallMoleculeDrug	DB08398	2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	CN1C(N)=NC2=NC=C(C=C12)C1=CC=CC=C1
7	Experimental	SmallMoleculeDrug	DB07712	3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	CCC1=C2C=C(O)C=CC2=NN1C1=CC=C(O)C=C1
8	Experimental	SmallMoleculeDrug	DB07708	3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	OC1=CC=C(C=C1)N1N=C2C=CC(O)=CC2=C1Cl
9	Experimental	SmallMoleculeDrug	DB08402	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID	OC(=O)C1=C(NC(=O)C2=C(Cl)C=C(Cl)C=C2)C=CC(OC2=NC=CC=N2)=C1
10	Experimental	SmallMoleculeDrug	DB08048	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	OC1=CC=C2C(NN=C2C2=CC=C(O)C=C2O)=C1
11	Experimental	SmallMoleculeDrug	DB08175	(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID	COC(C)(C)CCC[C@@](C)([H])C\C=C\C(\C)=C\C(O)=O
12	Investigational	SmallMoleculeDrug	DB01645	Genistein	OC1=CC=C(C=C1)C1=COC2=C(C(O)=CC(O)=C2)C1=O
13	Experimental	SmallMoleculeDrug	DB07863	2-chloro-5-nitro-N-phenylbenzamide	[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC1=CC=CC=C1
14	Experimental	SmallMoleculeDrug	DB07087	4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	[H][C@]1(C)CC[C@]2(CO)CO[C@]([H])(C3=CC=C(O)C=C3)[C@@]1([H])[C@@]2([H])C
15	Experimental	SmallMoleculeDrug	DB06898	4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol	CN1C(N)=NC2=C1C=C(C=N2)C1=CC=C(O)C=C1
16	Experimental	SmallMoleculeDrug	DB07707	(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL	[H][C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])[C@@]([H])(COC)C[C@]12C
17	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB13956	Estradiol valerate	[H][C@@]12CC[C@H](OC(=O)CCCC)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
18	Experimental	SmallMoleculeDrug	DB07932	dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate	[H][C@]12O[C@]([H])(C(C(=O)OC)=C1C(=O)OC)C(=C2C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
19	Experimental	SmallMoleculeDrug	DB07678	(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL	[H]\C(CC)=C(/[H])C1=C(O)C=C2CC[C@@]3([H])[C@]4([H])CC[C@]([H])(O)[C@@]4(C)CC[C@]3([H])C2=C1
20	Experimental	SmallMoleculeDrug	DB08047	4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol	OC1=CC(O)=C(C=C1)C1=NN(CC=C)C2=C1C=CC=C2C(F)(F)F
21	Experimental	SmallMoleculeDrug	DB07195	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	[H][C@]1(C)C=C(C)[C@]2([H])[C@]([H])(C)[C@@]1(CO)CO[C@]2([H])C1=CC=C(O)C=C1
22	Experimental	SmallMoleculeDrug	DB07086	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	[H][C@@]12C[C@@](CO)(CO[C@]1([H])C1=CC=C(O)C=C1)CC=C2C
23	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB13952	Estradiol acetate	[H][C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(OC(C)=O)=CC=C4[C@@]3([H])CC[C@]12C
24	Experimental	SmallMoleculeDrug	DB06871	17-METHYL-17-ALPHA-DIHYDROEQUILENIN	[H][C@@]12CC[C@@](C)(O)[C@@]1(C)CCC1=C2C=CC2=CC(O)=CC=C12
25	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB13955	Estradiol dienanthate	CCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(OC(=O)CCCCCC)=CC=C4[C@H]3CC[C@]12C
26	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB00783	Estradiol	[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
27	Experimental	SmallMoleculeDrug	DB08601	tributylstannanyl	CCCC[Sn](CCCC)CCCC
28	Experimental	SmallMoleculeDrug	DB02998	Methyltrienolone	[H][C@@]12CC[C@](C)(O)[C@@]1(C)C=CC1=C3CCC(=O)C=C3CC[C@@]21[H]
29	Experimental	SmallMoleculeDrug	DB07080	N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE	OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F
30	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB13953	Estradiol benzoate	[H][C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(OC(=O)C5=CC=CC=C5)=CC=C4[C@@]3([H])CC[C@]12C

20 predicted interactions (drugs) of input target (NCOA2): Nuclear receptor coactivator 2

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Investigational	SmallMoleculeDrug	DB04468	Afimoxifene	CC\C(=C(/C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1	55.8%
2	Approved	SmallMoleculeDrug	DB00675	Tamoxifen	CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1	55.6%
3	Experimental	SmallMoleculeDrug	DB03467	Naringenin	[H][C@]1(CC(=O)C2=C(O1)C=C(O)C=C2O)C1=CC=C(O)C=C1	51.4%
4	Approved; Withdrawn	SmallMoleculeDrug	DB04824	Phenolphthalein	OC1=CC=C(C=C1)C1(OC(=O)C2=CC=CC=C12)C1=CC=C(O)C=C1	50.6%
5	Experimental	SmallMoleculeDrug	DB06732	beta-Naphthoflavone	O=C1C=C(OC2=C1C1=CC=CC=C1C=C2)C1=CC=CC=C1	50.0%
6	Experimental	SmallMoleculeDrug	DB02746	Phthalic Acid	OC(=O)C1=CC=CC=C1C(O)=O	50.0%
7	Approved; Investigational	SmallMoleculeDrug	DB00539	Toremifene	CN(C)CCOC1=CC=C(C=C1)C(=C(\CCCl)C1=CC=CC=C1)\C1=CC=CC=C1	49.0%
8	Approved	SmallMoleculeDrug	DB09371	Norethynodrel	[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])CC(=O)CC3	48.5%
9	Approved; Investigational	SmallMoleculeDrug	DB13946	Testosterone undecanoate	CCCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	47.9%
10	Experimental	SmallMoleculeDrug	DB13869	2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol	COC1=C(O)C(\C=N\C2=CC=C(C)C=C2)=CC=C1	47.1%
11	Approved; Illicit	SmallMoleculeDrug	DB01185	Fluoxymesterone	[H][C@@]12CC[C@](C)(O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C	47.0%
12	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB04573	Estriol	[H][C@@]12C[C@@H](O)[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3	46.7%
13	Approved	SmallMoleculeDrug	DB01428	Oxybenzone	COC1=CC(O)=C(C=C1)C(=O)C1=CC=CC=C1	46.4%
14	Approved; Investigational	SmallMoleculeDrug	DB09070	Tibolone	[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC(=O)CC3)C[C@@]([H])(C)[C@@]21[H]	45.5%
15	Approved; Investigational	SmallMoleculeDrug	DB06249	Arzoxifene	COC1=CC=C(C=C1)C1=C(OC2=CC=C(OCCN3CCCCC3)C=C2)C2=C(S1)C=C(O)C=C2	45.3%
16	Approved; Vet approved	SmallMoleculeDrug	DB00396	Progesterone	[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C	45.1%
17	Illicit; Investigational	SmallMoleculeDrug	DB02901	Stanolone	[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C	44.4%
18	Experimental	SmallMoleculeDrug	DB08737	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL	[H][C@@]12CCC[C@]1([H])[C@@]([H])(OC1=CC=CC(O)=C21)C1=CC=C(O)C=C1	43.8%
19	Approved	SmallMoleculeDrug	DB00977	Ethinyl Estradiol	[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3	43.8%
20	Experimental	SmallMoleculeDrug	DB06927	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	OC1=CC=C(C=C1)C1=CC2=C(O1)C(CC#N)=CC(O)=C2	43.7%