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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15596
No. Gene UniProt ID Protein Name Pathway PDB
1 NCOA2 Q15596 Nuclear receptor coactivator 2 hsa04915; hsa04919

30 known interactions (drugs) of input target (NCOA2): Nuclear receptor coactivator 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB08595 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL Thumb
2 Approved;
SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb
3 Experimental SmallMoleculeDrug DB08773 RALOXIFENE CORE Thumb
4 Approved;
Vet approved
SmallMoleculeDrug DB13954 Estradiol cypionate Thumb
5 Experimental SmallMoleculeDrug DB08320 DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE Thumb
6 Investigational SmallMoleculeDrug DB08398 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Thumb
7 Experimental SmallMoleculeDrug DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL Thumb
8 Experimental SmallMoleculeDrug DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL Thumb
9 Experimental SmallMoleculeDrug DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Thumb
10 Experimental SmallMoleculeDrug DB08048 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL Thumb
11 Experimental SmallMoleculeDrug DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Thumb
12 Investigational SmallMoleculeDrug DB01645 Genistein Thumb
13 Experimental SmallMoleculeDrug DB07863 2-chloro-5-nitro-N-phenylbenzamide Thumb
14 Experimental SmallMoleculeDrug DB07087 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL Thumb
15 Experimental SmallMoleculeDrug DB06898 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol Thumb
16 Experimental SmallMoleculeDrug DB07707 (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL Thumb
17 Approved;
Vet approved
SmallMoleculeDrug DB13956 Estradiol valerate Thumb
18 Experimental SmallMoleculeDrug DB07932 dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate Thumb
19 Experimental SmallMoleculeDrug DB07678 (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL Thumb
20 Experimental SmallMoleculeDrug DB08047 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol Thumb
21 Experimental SmallMoleculeDrug DB07195 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL Thumb
22 Experimental SmallMoleculeDrug DB07086 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL Thumb
23 Approved;
Vet approved
SmallMoleculeDrug DB13952 Estradiol acetate Thumb
24 Experimental SmallMoleculeDrug DB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENIN Thumb
25 Approved;
Vet approved
SmallMoleculeDrug DB13955 Estradiol dienanthate Thumb
26 Approved;
Vet approved
SmallMoleculeDrug DB00783 Estradiol Thumb
27 Experimental SmallMoleculeDrug DB08601 tributylstannanyl Thumb
28 Experimental SmallMoleculeDrug DB02998 Methyltrienolone Thumb
30 Approved;
Vet approved
SmallMoleculeDrug DB13953 Estradiol benzoate Thumb

20 predicted interactions (drugs) of input target (NCOA2): Nuclear receptor coactivator 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB04468 Afimoxifene Thumb 55.8%
2 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 55.6%
3 Experimental SmallMoleculeDrug DB03467 Naringenin Thumb 51.4%
4 Approved;
SmallMoleculeDrug DB04824 Phenolphthalein Thumb 50.6%
5 Experimental SmallMoleculeDrug DB06732 beta-Naphthoflavone Thumb 50.0%
6 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 50.0%
7 Approved;
SmallMoleculeDrug DB00539 Toremifene Thumb 49.0%
8 Approved SmallMoleculeDrug DB09371 Norethynodrel Thumb 48.5%
9 Approved;
SmallMoleculeDrug DB13946 Testosterone undecanoate Thumb 47.9%
10 Experimental SmallMoleculeDrug DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Thumb 47.1%
11 Approved;
SmallMoleculeDrug DB01185 Fluoxymesterone Thumb 47.0%
12 Approved;
Vet approved
SmallMoleculeDrug DB04573 Estriol Thumb 46.7%
13 Approved SmallMoleculeDrug DB01428 Oxybenzone Thumb 46.4%
14 Approved;
SmallMoleculeDrug DB09070 Tibolone Thumb 45.5%
15 Approved;
SmallMoleculeDrug DB06249 Arzoxifene Thumb 45.3%
16 Approved;
Vet approved
SmallMoleculeDrug DB00396 Progesterone Thumb 45.1%
17 Illicit;
SmallMoleculeDrug DB02901 Stanolone Thumb 44.4%
18 Experimental SmallMoleculeDrug DB08737 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL Thumb 43.8%
19 Approved SmallMoleculeDrug DB00977 Ethinyl Estradiol Thumb 43.8%
20 Experimental SmallMoleculeDrug DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE Thumb 43.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.