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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q13621
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC12A1 Q13621 Solute carrier family 12 member 1 NA NA


11 known interactions (drugs) of input target (SLC12A1): Solute carrier family 12 member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00214 Torasemide Thumb
2 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb
3 Approved SmallMoleculeDrug DB00887 Bumetanide Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00903 Etacrynic acid Thumb
5 Approved SmallMoleculeDrug DB00310 Chlorthalidone Thumb
6 Approved;
Withdrawn		 SmallMoleculeDrug DB00761 Potassium Chloride Thumb
7 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb
9 Approved;
Vet approved		 SmallMoleculeDrug DB00695 Furosemide Thumb
10 Approved SmallMoleculeDrug DB02925 Piretanide Thumb
11 Approved;
Withdrawn		 SmallMoleculeDrug DB00534 Chlormerodrin Thumb


20 predicted interactions (drugs) of input target (SLC12A1): Solute carrier family 12 member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 35.7%
2 Approved;
Vet approved		 SmallMoleculeDrug DB01021 Trichlormethiazide Thumb 35.6%
3 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb 35.4%
4 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb 33.7%
5 Approved;
Investigational		 SmallMoleculeDrug DB09462 Glycerin Thumb 31.9%
6 Experimental SmallMoleculeDrug DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Thumb 29.3%
7 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 28.2%
8 Approved;
Vet approved		 SmallMoleculeDrug DB00819 Acetazolamide Thumb 28.1%
9 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb 27.9%
10 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 26.6%
11 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 26.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB03904 Urea Thumb 24.9%
13 Approved SmallMoleculeDrug DB00210 Adapalene Thumb 24.8%
14 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 23.2%
15 Approved;
Vet approved		 SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb 23.2%
16 Experimental SmallMoleculeDrug DB03039 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide Thumb 23.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB00482 Celecoxib Thumb 22.8%
18 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb 22.5%
19 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 22.4%
20 Experimental SmallMoleculeDrug DB02221 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide Thumb 22.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.