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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O60840
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA1F O60840 Voltage-dependent L-type calcium channel subunit alpha-1F hsa04010; hsa04020; hsa04022; hsa04024; hsa04260; hsa04261; hsa04270; hsa04723; hsa04725; hsa04726; hsa04727; hsa04911; hsa04912; hsa04921; hsa04924; hsa04925; hsa04927; hsa04934; hsa05010; hsa05410; hsa05412; hsa05414 NA


17 known interactions (drugs) of input target (CACNA1F): Voltage-dependent L-type calcium channel subunit alpha-1F
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB09238 Manidipine Thumb
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB09236 Lacidipine Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB09231 Benidipine Thumb
5 Approved SmallMoleculeDrug DB00825 Menthol Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB00393 Nimodipine Thumb
7 Approved;
Withdrawn
SmallMoleculeDrug DB11148 Butamben Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB04920 Clevidipine Thumb
9 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
10 Investigational;
Withdrawn
SmallMoleculeDrug DB01388 Mibefradil Thumb
11 Approved;
Investigational
SmallMoleculeDrug DB09232 Cilnidipine Thumb
12 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb
13 Approved;
Nutraceutical
SmallMoleculeDrug DB13961 Fish oil Thumb
14 Approved;
Investigational
SmallMoleculeDrug DB00568 Cinnarizine Thumb
15 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
16 Approved;
Experimental
SmallMoleculeDrug DB13746 Bioallethrin Thumb
17 Approved SmallMoleculeDrug DB00661 Verapamil Thumb


20 predicted interactions (drugs) of input target (CACNA1F): Voltage-dependent L-type calcium channel subunit alpha-1F
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 70.3%
2 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 69.6%
3 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 67.2%
4 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 66.9%
5 Approved;
Investigational
SmallMoleculeDrug DB01054 Nitrendipine Thumb 66.9%
6 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 66.8%
7 Approved;
Investigational
SmallMoleculeDrug DB06712 Nilvadipine Thumb 66.6%
8 Approved;
Investigational
SmallMoleculeDrug DB00270 Isradipine Thumb 65.7%
9 Approved;
Investigational
SmallMoleculeDrug DB01023 Felodipine Thumb 64.4%
10 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb 63.6%
11 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 60.3%
12 Approved;
Investigational
SmallMoleculeDrug DB09235 Efonidipine Thumb 53.8%
13 Approved;
Investigational
SmallMoleculeDrug DB09230 Azelnidipine Thumb 48.5%
14 Approved SmallMoleculeDrug DB09090 Pinaverium Thumb 46.5%
15 Approved;
Investigational
SmallMoleculeDrug DB12278 Propiverine Thumb 46.0%
16 Approved;
Investigational
SmallMoleculeDrug DB11633 Isavuconazole Thumb 44.1%
17 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 42.8%
18 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb 42.6%
19 Approved;
Nutraceutical
SmallMoleculeDrug DB01373 Calcium Thumb 41.6%
20 Approved;
Investigational
SmallMoleculeDrug DB09237 Levamlodipine Thumb 40.6%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.