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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P63316
No. Gene UniProt ID Protein Name Pathway PDB
1 TNNC1 P63316 Troponin C, slow skeletal and cardiac muscles hsa04020; hsa04260; hsa04261; hsa05410; hsa05414


8 known interactions (drugs) of input target (TNNC1): Troponin C, slow skeletal and cardiac muscles
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB01023 Felodipine Thumb
2 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb
3 Approved;
Nutraceutical
SmallMoleculeDrug DB01373 Calcium Thumb
4 Experimental SmallMoleculeDrug DB04513 N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB00831 Trifluoperazine Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB00922 Levosimendan Thumb
7 Experimental SmallMoleculeDrug DB03944 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One Thumb
8 Experimental SmallMoleculeDrug DB01375 Aluminium monostearate Thumb


20 predicted interactions (drugs) of input target (TNNC1): Troponin C, slow skeletal and cardiac muscles
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb 44.2%
2 Approved;
Withdrawn
SmallMoleculeDrug DB11148 Butamben Thumb 33.7%
3 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 33.0%
4 Approved;
Investigational
SmallMoleculeDrug DB06712 Nilvadipine Thumb 30.9%
5 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 30.7%
6 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 30.3%
7 Approved;
Investigational
SmallMoleculeDrug DB08872 Gabapentin Enacarbil Thumb 30.0%
8 Approved SmallMoleculeDrug DB00836 Loperamide Thumb 29.0%
9 Approved;
Investigational
SmallMoleculeDrug DB01118 Amiodarone Thumb 28.4%
10 Investigational SmallMoleculeDrug DB06098 PRLX 93936 Thumb 28.0%
11 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 27.4%
12 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 26.9%
13 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb 26.5%
14 Approved;
Investigational
SmallMoleculeDrug DB09130 Copper Thumb 26.2%
15 Approved;
Investigational
SmallMoleculeDrug DB01054 Nitrendipine Thumb 26.0%
16 Experimental SmallMoleculeDrug DB08039 (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Thumb 25.0%
17 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 24.8%
18 Approved;
Investigational
SmallMoleculeDrug DB00270 Isradipine Thumb 24.7%
19 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 24.7%
20 Approved;
Investigational
SmallMoleculeDrug DB11638 Artenimol Thumb 24.2%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.