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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q13224
No. Gene UniProt ID Protein Name Pathway PDB
1 GRIN2B Q13224 Glutamate receptor ionotropic, NMDA 2B hsa04014; hsa04015; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa04728; hsa05010; hsa05014; hsa05016; hsa05030; hsa05031; hsa05033; hsa05034; hsa05322 1S11; 1S2S; 2IPV


23 known interactions (drugs) of input target (GRIN2B): Glutamate receptor ionotropic, NMDA 2B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Nutraceutical
SmallMoleculeDrug DB01956 Taurine Thumb
2 Experimental;
Illicit;
Investigational
SmallMoleculeDrug DB01520 Tenocyclidine Thumb
3 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB08954 Ifenprodil Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB09481 Magnesium carbonate Thumb
5 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb
6 Approved SmallMoleculeDrug DB00949 Felbamate Thumb
7 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB06738 Ketobemidone Thumb
9 Approved;
Vet approved
SmallMoleculeDrug DB00418 Secobarbital Thumb
10 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
11 Investigational SmallMoleculeDrug DB05956 EVT-101 Thumb
12 Approved;
Investigational
SmallMoleculeDrug DB01043 Memantine Thumb
13 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb
14 Approved;
Investigational
SmallMoleculeDrug DB00659 Acamprosate Thumb
15 Approved;
Investigational
SmallMoleculeDrug DB01174 Phenobarbital Thumb
16 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb
17 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb
18 Approved SmallMoleculeDrug DB09409 Magnesium acetate tetrahydrate Thumb
19 Investigational SmallMoleculeDrug DB06741 Gavestinel Thumb
20 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb
21 Approved;
Investigational
SmallMoleculeDrug DB00996 Gabapentin Thumb
22 Approved;
Investigational
SmallMoleculeDrug DB06151 Acetylcysteine Thumb
23 Approved;
Investigational
SmallMoleculeDrug DB04896 Milnacipran Thumb


20 predicted interactions (drugs) of input target (GRIN2B): Glutamate receptor ionotropic, NMDA 2B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb 73.0%
2 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb 72.4%
3 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 60.0%
4 Experimental SmallMoleculeDrug DB01931 Dcka, 5,7-Dichlorokynurenic Acid Thumb 50.0%
5 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 48.9%
6 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 48.9%
7 Approved;
Experimental;
Investigational
SmallMoleculeDrug DB03929 D-Serine Thumb 47.2%
8 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 46.6%
9 Approved;
Investigational
SmallMoleculeDrug DB11901 Apalutamide Thumb 45.8%
10 Experimental;
Investigational
SmallMoleculeDrug DB08838 Agmatine Thumb 45.1%
11 Approved;
Vet approved
SmallMoleculeDrug DB00753 Isoflurane Thumb 44.4%
12 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 43.7%
13 Experimental SmallMoleculeDrug DB04620 Cycloleucine Thumb 42.5%
14 Approved;
Investigational
SmallMoleculeDrug DB11582 Thiocolchicoside Thumb 41.2%
15 Approved;
Illicit
SmallMoleculeDrug DB00237 Butabarbital Thumb 40.8%
16 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 40.8%
17 Approved;
Vet approved
SmallMoleculeDrug DB00794 Primidone Thumb 40.7%
18 Approved;
Illicit
SmallMoleculeDrug DB00306 Talbutal Thumb 40.5%
19 Approved;
Illicit
SmallMoleculeDrug DB00241 Butalbital Thumb 40.2%
20 Approved;
Vet approved
SmallMoleculeDrug DB01236 Sevoflurane Thumb 40.2%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.