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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O60391
No. Gene UniProt ID Protein Name Pathway PDB
1 GRIN3B O60391 Glutamate receptor ionotropic, NMDA 3B hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA


18 known interactions (drugs) of input target (GRIN3B): Glutamate receptor ionotropic, NMDA 3B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB00659 Acamprosate Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB06738 Ketobemidone Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB01174 Phenobarbital Thumb
4 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb
5 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB00996 Gabapentin Thumb
7 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb
8 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
9 Approved SmallMoleculeDrug DB09409 Magnesium acetate tetrahydrate Thumb
10 Approved;
Vet approved
SmallMoleculeDrug DB00418 Secobarbital Thumb
11 Investigational SmallMoleculeDrug DB06741 Gavestinel Thumb
12 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb
13 Approved;
Investigational
SmallMoleculeDrug DB09481 Magnesium carbonate Thumb
14 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb
15 Experimental;
Illicit;
Investigational
SmallMoleculeDrug DB01520 Tenocyclidine Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB04896 Milnacipran Thumb
17 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb
18 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb


20 predicted interactions (drugs) of input target (GRIN3B): Glutamate receptor ionotropic, NMDA 3B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB06151 Acetylcysteine Thumb 75.5%
2 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 74.5%
3 Approved SmallMoleculeDrug DB00949 Felbamate Thumb 67.3%
4 Approved;
Nutraceutical
SmallMoleculeDrug DB01956 Taurine Thumb 65.5%
5 Approved;
Investigational
SmallMoleculeDrug DB01043 Memantine Thumb 64.9%
6 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB08954 Ifenprodil Thumb 63.5%
7 Approved;
Experimental;
Investigational
SmallMoleculeDrug DB03929 D-Serine Thumb 49.6%
8 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 48.5%
9 Investigational SmallMoleculeDrug DB05956 EVT-101 Thumb 44.7%
10 Experimental SmallMoleculeDrug DB04620 Cycloleucine Thumb 44.1%
11 Experimental SmallMoleculeDrug DB01931 Dcka, 5,7-Dichlorokynurenic Acid Thumb 43.7%
12 Investigational SmallMoleculeDrug DB05824 CNS-5161 Thumb 42.0%
13 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 42.0%
14 Experimental;
Investigational
SmallMoleculeDrug DB08838 Agmatine Thumb 40.6%
15 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb 40.1%
16 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00228 Enflurane Thumb 40.0%
17 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb 39.5%
18 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb 39.3%
19 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb 39.0%
20 Approved;
Illicit
SmallMoleculeDrug DB01352 Aprobarbital Thumb 38.5%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.