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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q14500
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ12 Q14500 ATP-sensitive inward rectifier potassium channel 12 hsa04725; hsa04921 NA


3 known interactions (drugs) of input target (KCNJ12): ATP-sensitive inward rectifier potassium channel 12
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Withdrawn
SmallMoleculeDrug DB11148 Butamben Thumb
2 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB00204 Dofetilide Thumb


20 predicted interactions (drugs) of input target (KCNJ12): ATP-sensitive inward rectifier potassium channel 12
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00922 Levosimendan Thumb 34.0%
2 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 30.1%
3 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 27.2%
4 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 25.0%
5 Approved;
Investigational;
Withdrawn
BiotechDrug DB00055 Drotrecogin alfa Thumb 22.3%
6 Experimental;
Investigational
BiotechDrug DB14009 Medical Cannabis Thumb 21.9%
7 Approved;
Investigational
SmallMoleculeDrug DB11633 Isavuconazole Thumb 21.7%
8 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb 21.3%
9 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb 20.8%
10 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 20.2%
11 Approved;
Investigational;
Vet approved;
Withdrawn
SmallMoleculeDrug DB01186 Pergolide Thumb 20.1%
12 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb 19.7%
13 Experimental;
Investigational
SmallMoleculeDrug DB08838 Agmatine Thumb 19.6%
14 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb 19.0%
15 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb 18.5%
16 Approved;
Investigational
SmallMoleculeDrug DB09289 Tianeptine Thumb 18.1%
17 Approved;
Investigational
SmallMoleculeDrug DB09061 Cannabidiol Thumb 18.0%
18 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb 18.0%
19 Approved;
Investigational
SmallMoleculeDrug DB14011 Nabiximols Thumb 17.7%
20 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 17.6%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.