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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q8TCU5
No. Gene UniProt ID Protein Name Pathway PDB
1 GRIN3A Q8TCU5 Glutamate receptor ionotropic, NMDA 3A hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA


32 known interactions (drugs) of input target (GRIN3A): Glutamate receptor ionotropic, NMDA 3A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
2 Experimental;
Illicit;
Investigational
SmallMoleculeDrug DB01520 Tenocyclidine Thumb
3 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB09481 Magnesium carbonate Thumb
5 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb
6 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
7 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB06738 Ketobemidone Thumb
9 Approved;
Investigational
SmallMoleculeDrug DB01043 Memantine Thumb
10 Approved SmallMoleculeDrug DB00333 Methadone Thumb
11 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
12 Approved SmallMoleculeDrug DB00915 Amantadine Thumb
13 Approved;
Vet approved
SmallMoleculeDrug DB00418 Secobarbital Thumb
14 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb
15 Investigational SmallMoleculeDrug DB04926 Neramexane Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB00659 Acamprosate Thumb
17 Approved;
Investigational
SmallMoleculeDrug DB01174 Phenobarbital Thumb
18 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb
19 Approved;
Investigational
SmallMoleculeDrug DB00193 Tramadol Thumb
20 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb
21 Approved SmallMoleculeDrug DB09409 Magnesium acetate tetrahydrate Thumb
22 Investigational SmallMoleculeDrug DB06741 Gavestinel Thumb
23 Approved SmallMoleculeDrug DB00949 Felbamate Thumb
24 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb
25 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb
26 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb
27 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb
28 Approved;
Investigational
SmallMoleculeDrug DB00996 Gabapentin Thumb
29 Approved;
Investigational
SmallMoleculeDrug DB06151 Acetylcysteine Thumb
30 Approved;
Investigational
SmallMoleculeDrug DB04896 Milnacipran Thumb
31 Experimental;
Illicit
SmallMoleculeDrug DB01549 Rolicyclidine Thumb
32 Illicit SmallMoleculeDrug DB03575 Phencyclidine Thumb


20 predicted interactions (drugs) of input target (GRIN3A): Glutamate receptor ionotropic, NMDA 3A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 84.6%
2 Approved;
Nutraceutical
SmallMoleculeDrug DB01956 Taurine Thumb 67.1%
3 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB08954 Ifenprodil Thumb 60.7%
4 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 59.8%
5 Experimental;
Investigational
SmallMoleculeDrug DB08838 Agmatine Thumb 58.3%
6 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 56.8%
7 Approved;
Vet approved
SmallMoleculeDrug DB00753 Isoflurane Thumb 55.4%
8 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb 52.3%
9 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 52.0%
10 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb 49.6%
11 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 49.4%
12 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 48.1%
13 Approved;
Illicit
SmallMoleculeDrug DB01352 Aprobarbital Thumb 48.0%
14 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00228 Enflurane Thumb 47.0%
15 Approved;
Experimental;
Investigational
SmallMoleculeDrug DB03929 D-Serine Thumb 47.0%
16 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 45.9%
17 Approved;
Illicit
SmallMoleculeDrug DB00237 Butabarbital Thumb 45.9%
18 Investigational SmallMoleculeDrug DB05824 CNS-5161 Thumb 45.0%
19 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 44.0%
20 Approved;
Vet approved
SmallMoleculeDrug DB00572 Atropine Thumb 43.5%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.