QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics

 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q693P7
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA7 Q693P7 Alpha-7 nicotinic cholinergic receptor subunit NA NA


6 known interactions (drugs) of input target (CHRNA7): Alpha-7 nicotinic cholinergic receptor subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Experimental;
Illicit;
Investigational
SmallMoleculeDrug DB01520 Tenocyclidine Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB00193 Tramadol Thumb
3 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb
4 Investigational SmallMoleculeDrug DB06090 Bradanicline Thumb
5 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB01043 Memantine Thumb


20 predicted interactions (drugs) of input target (CHRNA7): Alpha-7 nicotinic cholinergic receptor subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 45.7%
2 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb 44.4%
3 Approved;
Investigational
SmallMoleculeDrug DB04896 Milnacipran Thumb 42.9%
4 Approved SmallMoleculeDrug DB00333 Methadone Thumb 42.6%
5 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb 41.2%
6 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb 41.1%
7 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 39.7%
8 Approved;
Investigational
SmallMoleculeDrug DB06738 Ketobemidone Thumb 38.9%
9 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb 38.5%
10 Approved SmallMoleculeDrug DB00949 Felbamate Thumb 38.4%
11 Approved;
Investigational
SmallMoleculeDrug DB06151 Acetylcysteine Thumb 38.1%
12 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb 37.1%
13 Approved;
Investigational
SmallMoleculeDrug DB09481 Magnesium carbonate Thumb 36.3%
14 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb 35.9%
15 Experimental;
Illicit
SmallMoleculeDrug DB01549 Rolicyclidine Thumb 35.8%
16 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 35.6%
17 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb 34.9%
18 Approved SmallMoleculeDrug DB09409 Magnesium acetate tetrahydrate Thumb 34.3%
19 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 34.2%
20 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb 34.1%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.