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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q12879
No. Gene UniProt ID Protein Name Pathway PDB
1 GRIN2A Q12879 Glutamate receptor ionotropic, NMDA 2A hsa04014; hsa04015; hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa04728; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034; hsa05322 3NFL


21 known interactions (drugs) of input target (GRIN2A): Glutamate receptor ionotropic, NMDA 2A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Vet approved
SmallMoleculeDrug DB00418 Secobarbital Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB00659 Acamprosate Thumb
3 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
4 Approved SmallMoleculeDrug DB00949 Felbamate Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB01174 Phenobarbital Thumb
6 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb
7 Approved;
Investigational
SmallMoleculeDrug DB00996 Gabapentin Thumb
8 Experimental;
Illicit;
Investigational
SmallMoleculeDrug DB01520 Tenocyclidine Thumb
9 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb
10 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
11 Approved SmallMoleculeDrug DB09409 Magnesium acetate tetrahydrate Thumb
12 Approved;
Investigational
SmallMoleculeDrug DB06151 Acetylcysteine Thumb
13 Approved;
Investigational
SmallMoleculeDrug DB01043 Memantine Thumb
14 Investigational SmallMoleculeDrug DB06741 Gavestinel Thumb
15 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB09481 Magnesium carbonate Thumb
17 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb
18 Approved;
Investigational
SmallMoleculeDrug DB06738 Ketobemidone Thumb
19 Approved;
Investigational
SmallMoleculeDrug DB04896 Milnacipran Thumb
20 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb
21 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb


20 predicted interactions (drugs) of input target (GRIN2A): Glutamate receptor ionotropic, NMDA 2A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb 74.9%
2 Approved;
Nutraceutical
SmallMoleculeDrug DB01956 Taurine Thumb 65.6%
3 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB08954 Ifenprodil Thumb 61.1%
4 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb 57.1%
5 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 52.9%
6 Investigational SmallMoleculeDrug DB05956 EVT-101 Thumb 52.9%
7 Approved;
Experimental;
Investigational
SmallMoleculeDrug DB03929 D-Serine Thumb 50.5%
8 Experimental;
Investigational
SmallMoleculeDrug DB08838 Agmatine Thumb 49.1%
9 Approved;
Vet approved
SmallMoleculeDrug DB00753 Isoflurane Thumb 44.3%
10 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 43.8%
11 Experimental SmallMoleculeDrug DB01931 Dcka, 5,7-Dichlorokynurenic Acid Thumb 42.9%
12 Experimental SmallMoleculeDrug DB04620 Cycloleucine Thumb 42.0%
13 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb 41.6%
14 Approved;
Investigational
SmallMoleculeDrug DB00193 Tramadol Thumb 41.4%
15 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 40.8%
16 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00228 Enflurane Thumb 40.6%
17 Approved;
Investigational
SmallMoleculeDrug DB09130 Copper Thumb 40.4%
18 Investigational SmallMoleculeDrug DB05824 CNS-5161 Thumb 40.2%
19 Approved;
Vet approved
SmallMoleculeDrug DB00794 Primidone Thumb 39.5%
20 Investigational SmallMoleculeDrug DB04926 Neramexane Thumb 38.8%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.