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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9GZZ6
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA10 Q9GZZ6 Neuronal acetylcholine receptor subunit alpha-10 hsa04080 NA


11 known interactions (drugs) of input target (CHRNA10): Neuronal acetylcholine receptor subunit alpha-10
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Investigational SmallMoleculeDrug DB05069 ATG003 Thumb
2 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB01116 Trimethaphan Thumb
4 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
5 Approved SmallMoleculeDrug DB00333 Methadone Thumb
6 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb
7 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb
8 Approved SmallMoleculeDrug DB01090 Pentolinium Thumb
9 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
10 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb
11 Approved SmallMoleculeDrug DB00184 Nicotine Thumb


20 predicted interactions (drugs) of input target (CHRNA10): Neuronal acetylcholine receptor subunit alpha-10
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 47.6%
2 Approved;
Vet approved
SmallMoleculeDrug DB00472 Fluoxetine Thumb 45.5%
3 Experimental;
Investigational
SmallMoleculeDrug DB08837 Tetraethylammonium Thumb 42.9%
4 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb 42.0%
5 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 40.8%
6 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb 40.1%
7 Approved;
Investigational
SmallMoleculeDrug DB00747 Scopolamine Thumb 36.5%
8 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 35.6%
9 Approved;
Investigational
SmallMoleculeDrug DB01273 Varenicline Thumb 35.3%
10 Approved;
Investigational
SmallMoleculeDrug DB09028 Cytisine Thumb 34.9%
11 Approved;
Investigational
SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb 34.3%
12 Approved;
Investigational
SmallMoleculeDrug DB00657 Mecamylamine Thumb 31.8%
13 Approved;
Investigational
SmallMoleculeDrug DB09061 Cannabidiol Thumb 30.4%
14 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb 30.2%
15 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb 30.0%
16 Approved;
Investigational
SmallMoleculeDrug DB00193 Tramadol Thumb 29.7%
17 Approved;
Vet approved
SmallMoleculeDrug DB00572 Atropine Thumb 29.7%
18 Approved SmallMoleculeDrug DB01226 Mivacurium Thumb 27.5%
19 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00143 Glutathione Thumb 27.5%
20 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 27.4%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.