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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q14654
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ11 Q14654 ATP-sensitive inward rectifier potassium channel 11 hsa04911; hsa04930 NA


11 known interactions (drugs) of input target (KCNJ11): ATP-sensitive inward rectifier potassium channel 11
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Withdrawn
SmallMoleculeDrug DB11148 Butamben Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB11633 Isavuconazole Thumb
3 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB00839 Tolazamide Thumb
5 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb
6 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb
7 Approved;
Investigational
SmallMoleculeDrug DB00922 Levosimendan Thumb
8 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb
9 Approved SmallMoleculeDrug DB01016 Glyburide Thumb
10 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
11 Approved SmallMoleculeDrug DB00661 Verapamil Thumb


20 predicted interactions (drugs) of input target (KCNJ11): ATP-sensitive inward rectifier potassium channel 11
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 60.4%
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 47.8%
3 Approved;
Investigational
SmallMoleculeDrug DB01251 Gliquidone Thumb 47.0%
4 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 44.5%
5 Investigational;
Withdrawn
SmallMoleculeDrug DB01388 Mibefradil Thumb 40.2%
6 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb 38.0%
7 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 37.7%
8 Approved;
Investigational
SmallMoleculeDrug DB09238 Manidipine Thumb 37.6%
9 Approved;
Experimental
SmallMoleculeDrug DB13746 Bioallethrin Thumb 37.3%
10 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 35.8%
11 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb 35.0%
12 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 34.6%
13 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb 34.4%
14 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 34.3%
15 Approved;
Investigational
SmallMoleculeDrug DB00568 Cinnarizine Thumb 34.2%
16 Approved;
Investigational
SmallMoleculeDrug DB09231 Benidipine Thumb 33.6%
17 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb 33.1%
18 Approved;
Investigational
SmallMoleculeDrug DB09236 Lacidipine Thumb 31.8%
19 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB00914 Phenformin Thumb 31.7%
20 Approved;
Investigational
SmallMoleculeDrug DB09232 Cilnidipine Thumb 31.7%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.