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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O43497
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA1G O43497 Voltage-dependent T-type calcium channel subunit alpha-1G hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04930; hsa04934 NA


17 known interactions (drugs) of input target (CACNA1G): Voltage-dependent T-type calcium channel subunit alpha-1G
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB09238 Manidipine Thumb
2 Approved SmallMoleculeDrug DB00347 Trimethadione Thumb
3 Approved;
Withdrawn
SmallMoleculeDrug DB11148 Butamben Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB00909 Zonisamide Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB09061 Cannabidiol Thumb
6 Experimental;
Investigational
BiotechDrug DB14009 Medical Cannabis Thumb
7 Approved SmallMoleculeDrug DB00593 Ethosuximide Thumb
8 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb
9 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
10 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
11 Approved;
Investigational
SmallMoleculeDrug DB09231 Benidipine Thumb
12 Investigational;
Withdrawn
SmallMoleculeDrug DB01388 Mibefradil Thumb
13 Approved SmallMoleculeDrug DB05246 Methsuximide Thumb
14 Approved;
Investigational
SmallMoleculeDrug DB00568 Cinnarizine Thumb
15 Approved;
Investigational
SmallMoleculeDrug DB14011 Nabiximols Thumb
16 Approved;
Experimental
SmallMoleculeDrug DB13746 Bioallethrin Thumb
17 Approved SmallMoleculeDrug DB00661 Verapamil Thumb


20 predicted interactions (drugs) of input target (CACNA1G): Voltage-dependent T-type calcium channel subunit alpha-1G
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 64.8%
2 Approved SmallMoleculeDrug DB00825 Menthol Thumb 63.8%
3 Approved;
Investigational
SmallMoleculeDrug DB09236 Lacidipine Thumb 60.5%
4 Approved;
Investigational
SmallMoleculeDrug DB00393 Nimodipine Thumb 58.7%
5 Approved;
Investigational
SmallMoleculeDrug DB09235 Efonidipine Thumb 57.9%
6 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 55.3%
7 Approved;
Investigational
SmallMoleculeDrug DB01054 Nitrendipine Thumb 54.8%
8 Approved;
Investigational
SmallMoleculeDrug DB00270 Isradipine Thumb 54.2%
9 Approved;
Nutraceutical
SmallMoleculeDrug DB13961 Fish oil Thumb 54.1%
10 Approved;
Investigational
SmallMoleculeDrug DB09232 Cilnidipine Thumb 53.1%
11 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb 52.5%
12 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb 51.4%
13 Approved;
Investigational
SmallMoleculeDrug DB01118 Amiodarone Thumb 51.1%
14 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 50.1%
15 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 50.0%
16 Approved;
Investigational
SmallMoleculeDrug DB01023 Felodipine Thumb 49.9%
17 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb 48.3%
18 Approved SmallMoleculeDrug DB00617 Paramethadione Thumb 46.0%
19 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 45.7%
20 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 45.1%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.