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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q13936
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA1C Q13936 Voltage-dependent L-type calcium channel subunit alpha-1C hsa04010; hsa04020; hsa04022; hsa04024; hsa04260; hsa04261; hsa04270; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04742; hsa04911; hsa04912; hsa04921; hsa04924; hsa04925; hsa04927; hsa04930; hsa04934; hsa05010; hsa05031; hsa05410; hsa05412; hsa05414 1T0J; 2BE6; 2F3Y; 2F3Z; 2LQC; 3G43; 3OXQ


35 known interactions (drugs) of input target (CACNA1C): Voltage-dependent L-type calcium channel subunit alpha-1C
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB09236 Lacidipine Thumb
3 Investigational;
Withdrawn
SmallMoleculeDrug DB01388 Mibefradil Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB11633 Isavuconazole Thumb
5 Approved;
Nutraceutical
SmallMoleculeDrug DB01373 Calcium Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb
7 Approved;
Investigational
SmallMoleculeDrug DB09231 Benidipine Thumb
8 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00653 Magnesium sulfate Thumb
9 Approved;
Nutraceutical
SmallMoleculeDrug DB13961 Fish oil Thumb
10 Approved SmallMoleculeDrug DB09227 Barnidipine Thumb
11 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
12 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
13 Approved;
Investigational
SmallMoleculeDrug DB00393 Nimodipine Thumb
14 Approved;
Investigational
SmallMoleculeDrug DB04920 Clevidipine Thumb
15 Approved;
Investigational
SmallMoleculeDrug DB09235 Efonidipine Thumb
16 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
17 Approved;
Investigational
SmallMoleculeDrug DB09238 Manidipine Thumb
18 Approved;
Investigational
SmallMoleculeDrug DB06712 Nilvadipine Thumb
19 Approved;
Investigational
SmallMoleculeDrug DB01023 Felodipine Thumb
20 Approved;
Investigational
SmallMoleculeDrug DB00270 Isradipine Thumb
21 Approved;
Investigational
SmallMoleculeDrug DB12278 Propiverine Thumb
22 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb
23 Approved;
Investigational
SmallMoleculeDrug DB09232 Cilnidipine Thumb
24 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb
25 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
26 Approved;
Experimental
SmallMoleculeDrug DB13746 Bioallethrin Thumb
27 Approved;
Investigational
SmallMoleculeDrug DB09237 Levamlodipine Thumb
28 Approved;
Withdrawn
SmallMoleculeDrug DB11148 Butamben Thumb
29 Approved SmallMoleculeDrug DB00825 Menthol Thumb
30 Approved;
Investigational
SmallMoleculeDrug DB06751 Drotaverine Thumb
31 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
32 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb
33 Approved;
Investigational
SmallMoleculeDrug DB00568 Cinnarizine Thumb
34 Approved;
Investigational
SmallMoleculeDrug DB01054 Nitrendipine Thumb
35 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb


20 predicted interactions (drugs) of input target (CACNA1C): Voltage-dependent L-type calcium channel subunit alpha-1C
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB09090 Pinaverium Thumb 57.6%
2 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb 54.1%
3 Approved;
Investigational
SmallMoleculeDrug DB08872 Gabapentin Enacarbil Thumb 51.0%
4 Approved;
Investigational
SmallMoleculeDrug DB09230 Azelnidipine Thumb 48.9%
5 Approved;
Investigational
SmallMoleculeDrug DB00996 Gabapentin Thumb 47.7%
6 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb 47.3%
7 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 46.0%
8 Approved;
Investigational
SmallMoleculeDrug DB01118 Amiodarone Thumb 41.2%
9 Approved SmallMoleculeDrug DB00617 Paramethadione Thumb 38.8%
10 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb 38.8%
11 Approved;
Investigational
SmallMoleculeDrug DB09061 Cannabidiol Thumb 38.5%
12 Approved;
Investigational
SmallMoleculeDrug DB01069 Promethazine Thumb 36.5%
13 Experimental;
Investigational
SmallMoleculeDrug DB08838 Agmatine Thumb 35.9%
14 Approved SmallMoleculeDrug DB04838 Cyclandelate Thumb 35.7%
15 Approved;
Investigational
SmallMoleculeDrug DB04842 Fluspirilene Thumb 35.0%
16 Experimental;
Investigational
BiotechDrug DB14009 Medical Cannabis Thumb 32.6%
17 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb 31.2%
18 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 31.1%
19 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb 30.6%
20 Approved;
Investigational
SmallMoleculeDrug DB00343 Diltiazem Thumb 28.8%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.