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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9H252
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNH6 Q9H252 Potassium voltage-gated channel subfamily H member 6 NA NA


5 known interactions (drugs) of input target (KCNH6): Potassium voltage-gated channel subfamily H member 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb
2 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
3 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb
4 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
5 Approved SmallMoleculeDrug DB01162 Terazosin Thumb


20 predicted interactions (drugs) of input target (KCNH6): Potassium voltage-gated channel subfamily H member 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00908 Quinidine Thumb 43.7%
2 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 42.6%
3 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb 40.8%
4 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 39.0%
5 Approved;
Investigational
SmallMoleculeDrug DB01136 Carvedilol Thumb 36.3%
6 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 35.7%
7 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb 34.2%
8 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb 33.5%
9 Approved;
Investigational
SmallMoleculeDrug DB00346 Alfuzosin Thumb 33.4%
10 Approved;
Vet approved
SmallMoleculeDrug DB00668 Epinephrine Thumb 31.5%
11 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb 31.0%
12 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb 30.7%
13 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00143 Glutathione Thumb 30.4%
14 Approved;
Investigational
SmallMoleculeDrug DB00706 Tamsulosin Thumb 30.1%
15 Approved;
Investigational
SmallMoleculeDrug DB00935 Oxymetazoline Thumb 29.6%
16 Approved;
Investigational
SmallMoleculeDrug DB13025 Tiapride Thumb 29.6%
17 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb 29.4%
18 Approved;
Withdrawn
SmallMoleculeDrug DB01149 Nefazodone Thumb 29.3%
19 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb 29.3%
20 Approved;
Withdrawn
SmallMoleculeDrug DB00679 Thioridazine Thumb 29.2%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.