QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9Y5N1
No. Gene UniProt ID Protein Name Pathway PDB
1 HRH3 Q9Y5N1 Histamine H3 receptor hsa04080 NA


5 known interactions (drugs) of input target (HRH3): Histamine H3 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB05381 Histamine Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB11642 Pitolisant Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB06698 Betahistine Thumb
4 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
5 Investigational SmallMoleculeDrug DB05080 OBE101 Thumb


20 predicted interactions (drugs) of input target (HRH3): Histamine H3 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 51.2%
2 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 45.3%
3 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb 44.0%
4 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 43.9%
5 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 40.2%
6 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 39.6%
7 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 38.9%
8 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb 38.4%
9 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 38.3%
10 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 38.1%
11 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 37.6%
12 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB06144 Sertindole Thumb 37.0%
13 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 36.9%
14 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb 36.9%
15 Approved;
Withdrawn
SmallMoleculeDrug DB01149 Nefazodone Thumb 36.5%
16 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 36.4%
17 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 36.2%
18 Approved;
Investigational
SmallMoleculeDrug DB00734 Risperidone Thumb 34.8%
19 Approved;
Investigational
SmallMoleculeDrug DB09128 Brexpiprazole Thumb 34.4%
20 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 34.4%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.