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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9NZV8
No. Gene UniProt ID Protein Name Pathway PDB
1 KCND2 Q9NZV8 Potassium voltage-gated channel subfamily D member 2 hsa04726 NA


4 known interactions (drugs) of input target (KCND2): Potassium voltage-gated channel subfamily D member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
3 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
4 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb


20 predicted interactions (drugs) of input target (KCND2): Potassium voltage-gated channel subfamily D member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00934 Maprotiline Thumb 41.2%
2 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 41.0%
3 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 40.6%
4 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 40.0%
5 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 40.0%
6 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb 39.7%
7 Approved;
Investigational
SmallMoleculeDrug DB06217 Vernakalant Thumb 38.4%
8 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 38.2%
9 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 37.9%
10 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 37.2%
11 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 36.7%
12 Approved;
Withdrawn
SmallMoleculeDrug DB01149 Nefazodone Thumb 36.6%
13 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 35.9%
14 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb 35.7%
15 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 35.4%
16 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 35.1%
17 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb 34.2%
18 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 34.1%
19 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB06144 Sertindole Thumb 34.0%
20 Approved;
Investigational
SmallMoleculeDrug DB00568 Cinnarizine Thumb 34.0%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.