QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics

 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9H3N8
No. Gene UniProt ID Protein Name Pathway PDB
1 HRH4 Q9H3N8 Histamine H4 receptor hsa04080 NA


10 known interactions (drugs) of input target (HRH4): Histamine H4 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
2 Investigational SmallMoleculeDrug DB05032 REV131 Thumb
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
4 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb
5 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB05381 Histamine Thumb
7 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb
9 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
10 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb


20 predicted interactions (drugs) of input target (HRH4): Histamine H4 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 75.1%
2 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 74.0%
3 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 73.1%
4 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 71.8%
5 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 71.7%
6 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 71.5%
7 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 70.9%
8 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 70.9%
9 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb 68.7%
10 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 68.6%
11 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 68.5%
12 Approved;
Investigational
SmallMoleculeDrug DB00934 Maprotiline Thumb 64.6%
13 Approved;
Investigational
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 64.6%
14 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 63.6%
15 Approved;
Investigational
SmallMoleculeDrug DB00734 Risperidone Thumb 63.4%
16 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 61.5%
17 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb 60.2%
18 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 60.1%
19 Approved;
Investigational
SmallMoleculeDrug DB01200 Bromocriptine Thumb 60.0%
20 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 60.0%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.