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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P30939
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR1F P30939 5-hydroxytryptamine receptor 1F hsa04024; hsa04080; hsa04726; hsa04742 NA


14 known interactions (drugs) of input target (HTR1F): 5-hydroxytryptamine receptor 1F
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB13025 Tiapride Thumb
2 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB00315 Zolmitriptan Thumb
4 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
5 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb
6 Approved;
Investigational
SmallMoleculeDrug DB00216 Eletriptan Thumb
7 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB00952 Naratriptan Thumb
9 Approved SmallMoleculeDrug DB00953 Rizatriptan Thumb
10 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
11 Approved;
Experimental
SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
12 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
13 Approved;
Investigational
SmallMoleculeDrug DB00669 Sumatriptan Thumb
14 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb


20 predicted interactions (drugs) of input target (HTR1F): 5-hydroxytryptamine receptor 1F
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 74.9%
2 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 72.9%
3 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 72.0%
4 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 71.6%
5 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 69.5%
6 Approved;
Investigational
SmallMoleculeDrug DB00589 Lisuride Thumb 68.6%
7 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 68.3%
8 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 68.2%
9 Approved;
Investigational
SmallMoleculeDrug DB00714 Apomorphine Thumb 67.8%
10 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 67.4%
11 Approved;
Investigational
SmallMoleculeDrug DB04948 Lofexidine Thumb 67.0%
12 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 67.0%
13 Approved;
Investigational
SmallMoleculeDrug DB09068 Vortioxetine Thumb 66.5%
14 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 66.3%
15 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 65.6%
16 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 65.5%
17 Approved;
Investigational
SmallMoleculeDrug DB00413 Pramipexole Thumb 65.5%
18 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 64.9%
19 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 64.5%
20 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 64.3%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.