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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q99720
No. Gene UniProt ID Protein Name Pathway PDB
1 SIGMAR1 Q99720 Sigma non-opioid intracellular receptor 1 NA NA


13 known interactions (drugs) of input target (SIGMAR1): Sigma non-opioid intracellular receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB11186 Pentoxyverine Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Investigational SmallMoleculeDrug DB06174 Noscapine Thumb
4 Experimental;
Illicit
SmallMoleculeDrug DB01488 Dimethyltryptamine Thumb
5 Approved;
Withdrawn
SmallMoleculeDrug DB00409 Remoxipride Thumb
6 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb
7 Approved SmallMoleculeDrug DB01104 Sertraline Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB09014 Captodiame Thumb
9 Approved;
Illicit
SmallMoleculeDrug DB00907 Cocaine Thumb
10 Approved;
Vet approved
SmallMoleculeDrug DB00652 Pentazocine Thumb
11 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
12 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
13 Illicit SmallMoleculeDrug DB03575 Phencyclidine Thumb


20 predicted interactions (drugs) of input target (SIGMAR1): Sigma non-opioid intracellular receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 68.8%
2 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 65.7%
3 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb 63.0%
4 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 59.3%
5 Approved;
Investigational
SmallMoleculeDrug DB00193 Tramadol Thumb 58.9%
6 Approved;
Vet approved
SmallMoleculeDrug DB00420 Promazine Thumb 55.0%
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 54.5%
8 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 54.4%
9 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 54.0%
10 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 53.5%
11 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb 53.3%
12 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb 52.5%
13 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 52.4%
14 Approved;
Vet approved
SmallMoleculeDrug DB00472 Fluoxetine Thumb 51.9%
15 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 51.3%
16 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb 50.3%
17 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 50.1%
18 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 49.7%
19 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 49.5%
20 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 48.2%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.