QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics

 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P47898
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR5A P47898 5-hydroxytryptamine receptor 5A hsa04020; hsa04080; hsa04726 NA


3 known interactions (drugs) of input target (HTR5A): 5-hydroxytryptamine receptor 5A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb


20 predicted interactions (drugs) of input target (HTR5A): 5-hydroxytryptamine receptor 5A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 67.9%
2 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb 60.8%
3 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 60.0%
4 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 59.7%
5 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 57.2%
6 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb 57.1%
7 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 56.9%
8 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 55.5%
9 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 54.9%
10 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb 54.4%
11 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb 54.3%
12 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 54.1%
13 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 53.3%
14 Approved;
Experimental
SmallMoleculeDrug DB13345 Dihydroergocristine Thumb 52.9%
15 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb 52.0%
16 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 51.3%
17 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 51.0%
18 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 50.6%
19 Approved;
Investigational
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 50.3%
20 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb 50.1%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.