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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q12809
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNH2 Q12809 Potassium voltage-gated channel subfamily H member 2 NA 1BYW; 1UJL; 2L0W; 2L1M; 2L4R; 2LE7; 4HP9; 4HQA


47 known interactions (drugs) of input target (KCNH2): Potassium voltage-gated channel subfamily H member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB01100 Pimozide Thumb
2 Approved;
Withdrawn
SmallMoleculeDrug DB01244 Bepridil Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB11633 Isavuconazole Thumb
4 Approved SmallMoleculeDrug DB01182 Propafenone Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb
6 Approved SmallMoleculeDrug DB11090 Potassium nitrate Thumb
7 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
8 Approved;
Withdrawn
SmallMoleculeDrug DB00342 Terfenadine Thumb
9 Investigational SmallMoleculeDrug DB06457 Tecastemizole Thumb
10 Approved SmallMoleculeDrug DB01035 Procainamide Thumb
11 Approved;
Withdrawn
SmallMoleculeDrug DB01149 Nefazodone Thumb
12 Investigational SmallMoleculeDrug DB04957 Azimilide Thumb
13 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
14 Approved;
Investigational
SmallMoleculeDrug DB11186 Pentoxyverine Thumb
15 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB11642 Pitolisant Thumb
17 Approved;
Withdrawn
SmallMoleculeDrug DB00679 Thioridazine Thumb
18 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb
19 Approved;
Investigational
SmallMoleculeDrug DB00276 Amsacrine Thumb
20 Approved;
Investigational
SmallMoleculeDrug DB01074 Perhexiline Thumb
21 Approved;
Withdrawn
SmallMoleculeDrug DB00637 Astemizole Thumb
22 Approved;
Vet approved
SmallMoleculeDrug DB00472 Fluoxetine Thumb
23 Approved SmallMoleculeDrug DB00489 Sotalol Thumb
24 Approved;
Investigational
SmallMoleculeDrug DB00346 Alfuzosin Thumb
25 Approved;
Investigational
SmallMoleculeDrug DB06217 Vernakalant Thumb
26 Approved SmallMoleculeDrug DB01162 Terazosin Thumb
27 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB06144 Sertindole Thumb
28 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB00604 Cisapride Thumb
29 Approved;
Investigational
SmallMoleculeDrug DB01026 Ketoconazole Thumb
30 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
31 Approved;
Investigational
SmallMoleculeDrug DB01136 Carvedilol Thumb
32 Approved;
Withdrawn
SmallMoleculeDrug DB01195 Flecainide Thumb
33 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB11386 Chlorobutanol Thumb
34 Approved;
Investigational
SmallMoleculeDrug DB00176 Fluvoxamine Thumb
35 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00199 Erythromycin Thumb
36 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
37 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb
38 Approved SmallMoleculeDrug DB01211 Clarithromycin Thumb
39 Approved;
Investigational
SmallMoleculeDrug DB00204 Dofetilide Thumb
40 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
41 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb
42 Approved;
Investigational
SmallMoleculeDrug DB00908 Quinidine Thumb
43 Approved;
Investigational
SmallMoleculeDrug DB00455 Loratadine Thumb
44 Approved;
Investigational
SmallMoleculeDrug DB01118 Amiodarone Thumb
45 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb
46 Approved;
Investigational
SmallMoleculeDrug DB00537 Ciprofloxacin Thumb
47 Approved SmallMoleculeDrug DB01218 Halofantrine Thumb


20 predicted interactions (drugs) of input target (KCNH2): Potassium voltage-gated channel subfamily H member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 74.1%
2 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 70.2%
3 Approved;
Investigational
SmallMoleculeDrug DB00622 Nicardipine Thumb 67.5%
4 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 67.1%
5 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb 64.3%
6 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00143 Glutathione Thumb 63.8%
7 Approved;
Illicit
SmallMoleculeDrug DB00907 Cocaine Thumb 63.5%
8 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb 62.2%
9 Experimental SmallMoleculeDrug DB09203 Synephrine Thumb 60.8%
10 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb 60.3%
11 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 60.0%
12 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb 59.8%
13 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb 59.4%
14 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 59.1%
15 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 58.0%
16 Approved;
Investigational
SmallMoleculeDrug DB09128 Brexpiprazole Thumb 58.0%
17 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 57.8%
18 Approved;
Investigational
SmallMoleculeDrug DB01608 Propericiazine Thumb 57.6%
19 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 57.3%
20 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 57.2%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.