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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q13639
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR4 Q13639 5-hydroxytryptamine receptor 4 hsa04020; hsa04024; hsa04080; hsa04726 NA


17 known interactions (drugs) of input target (HTR4): 5-hydroxytryptamine receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Investigational SmallMoleculeDrug DB05905 TD-2749 Thumb
2 Investigational SmallMoleculeDrug DB04917 Renzapride Thumb
3 Investigational SmallMoleculeDrug DB06422 Ticalopride Thumb
4 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb
5 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
6 Investigational SmallMoleculeDrug DB05542 Naronapride Thumb
7 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB00604 Cisapride Thumb
8 Approved SmallMoleculeDrug DB06480 Prucalopride Thumb
9 Approved;
Investigational
SmallMoleculeDrug DB13025 Tiapride Thumb
10 Investigational SmallMoleculeDrug DB04873 Piboserod Thumb
11 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
12 Investigational SmallMoleculeDrug DB12702 Velusetrag Thumb
13 Approved;
Experimental
SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
14 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB01079 Tegaserod Thumb
15 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB08810 Cinitapride Thumb
17 Approved;
Investigational
SmallMoleculeDrug DB01233 Metoclopramide Thumb


20 predicted interactions (drugs) of input target (HTR4): 5-hydroxytryptamine receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 69.0%
2 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 62.7%
3 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 62.4%
4 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb 61.9%
5 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 60.0%
6 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb 59.2%
7 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 58.9%
8 Approved;
Investigational
SmallMoleculeDrug DB09286 Pipamperone Thumb 58.2%
9 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 58.2%
10 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 58.1%
11 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 58.0%
12 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 57.4%
13 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb 57.1%
14 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 56.7%
15 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 56.6%
16 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 55.5%
17 Approved;
Investigational
SmallMoleculeDrug DB01200 Bromocriptine Thumb 55.4%
18 Approved;
Investigational
SmallMoleculeDrug DB00589 Lisuride Thumb 55.3%
19 Approved;
Investigational
SmallMoleculeDrug DB00268 Ropinirole Thumb 54.8%
20 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb 54.5%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.