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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical-target; # of requested predictions: 20; Secondary interactions: yes
Input drug 1: Loxapine
Input target 1: ADA2A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA2A P08913 Alpha-2A adrenergic receptor hsa04022; hsa04080 1HLL; 1HO9; 1HOD; 1HOF


32 known interactions (targets) of input drug (DB00408): Loxapine
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA2C P18825 Alpha-2C adrenergic receptor hsa04022; hsa04080 NA
2 HRH1 P35367 Histamine H1 receptor hsa04020; hsa04080; hsa04750 3RZE
3 HTR2C P28335 5-hydroxytryptamine receptor 2C hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA
4 SLC6A3 Q01959 Sodium-dependent dopamine transporter hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA
5 HTR1B P28222 5-hydroxytryptamine receptor 1B hsa04024; hsa04080; hsa04726; hsa04742 2G1X; 4IAQ; 4IAR
6 HTR2A P28223 5-hydroxytryptamine receptor 2A hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA
7 SLC6A4 P31645 Sodium-dependent serotonin transporter hsa04726 NA
8 CHRM3 P20309 Muscarinic acetylcholine receptor M3 hsa04020; hsa04080; hsa04725; hsa04742; hsa04810; hsa04911; hsa04970; hsa04971; hsa04972 2CSA
9 CHRM4 P08173 Muscarinic acetylcholine receptor M4 hsa04080; hsa04725; hsa04810 NA
10 ADRA2B P18089 Alpha-2B adrenergic receptor hsa04022; hsa04080 2CVA
11 CHRM5 P08912 Muscarinic acetylcholine receptor M5 hsa04020; hsa04080; hsa04725; hsa04810 NA
12 DRD1 P21728 D(1A) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05031; hsa05032; hsa05034 1OZ5
13 CHRM2 P08172 Muscarinic acetylcholine receptor M2 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 1LUB; 3UON; 4MQS; 4MQT
14 ADRA1B P35368 Alpha-1B adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04261; hsa04270; hsa04970 NA
15 ADRB1 P08588 Beta-1 adrenergic receptor hsa04020; hsa04022; hsa04024; hsa04080; hsa04261; hsa04540; hsa04923; hsa04924; hsa04970; hsa05414 2LSQ
16 HTR1A P08908 5-hydroxytryptamine receptor 1A hsa04024; hsa04080; hsa04726; hsa04742 NA
17 HTR7 P34969 5-hydroxytryptamine receptor 7 hsa04014; hsa04020; hsa04080; hsa04726 NA
18 CHRM1 P11229 Muscarinic acetylcholine receptor M1 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 NA
19 HRH2 P25021 Histamine H2 receptor hsa04020; hsa04080; hsa04971 NA
20 HTR3A P46098 5-hydroxytryptamine receptor 3A hsa04726; hsa04742 NA
21 HTR5A P47898 5-hydroxytryptamine receptor 5A hsa04020; hsa04080; hsa04726 NA
22 SLC6A2 P23975 Sodium-dependent noradrenaline transporter NA NA
23 ADRA1A P35348 Alpha-1A adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04152; hsa04261; hsa04270; hsa04970 NA
24 HTR1E P28566 5-hydroxytryptamine receptor 1E hsa04024; hsa04080; hsa04726; hsa04742 NA
25 DRD5 P21918 D(1B) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04728 NA
26 HTR6 P50406 5-hydroxytryptamine receptor 6 hsa04020; hsa04024; hsa04080; hsa04726 NA
27 HTR1D P28221 5-hydroxytryptamine receptor 1D hsa04024; hsa04080; hsa04726; hsa04742 NA
28 HRH4 Q9H3N8 Histamine H4 receptor hsa04080 NA
29 DRD2 P14416 D(2) dopamine receptor hsa04015; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05034 1I15; 5AER
30 DRD3 P35462 D(3) dopamine receptor hsa04080; hsa04728 3PBL
31 DRD4 P21917 D(4) dopamine receptor hsa04080; hsa04728 NA
32 ADRA2A P08913 Alpha-2A adrenergic receptor hsa04022; hsa04080 1HLL; 1HO9; 1HOD; 1HOF


20 predicted interactions (targets) of input drug (DB00408): Loxapine
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 HTR2B P41595 5-hydroxytryptamine receptor 2B hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 4IB4; 4NC3 95.8%
2 ADRA1D P25100 Alpha-1D adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04261; hsa04270; hsa04970 NA 95.3%
3 HTR1F P30939 5-hydroxytryptamine receptor 1F hsa04024; hsa04080; hsa04726; hsa04742 NA 93.2%
4 HTR3B O95264 5-hydroxytryptamine receptor 3B hsa04726; hsa04742 NA 92.7%
5 HTR3D Q70Z44 5-hydroxytryptamine receptor 3D hsa04726; hsa04742 NA 91.2%
6 HTR3E A5X5Y0 5-hydroxytryptamine receptor 3E hsa04726; hsa04742 NA 91.2%
7 HTR3C Q8WXA8 5-hydroxytryptamine receptor 3C hsa04726; hsa04742 NA 91.2%
8 ADRB3 P13945 Beta-3 adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04714; hsa04923; hsa04924; hsa04970 2CDW 90.6%
9 SMPD1 P17405 Sphingomyelin phosphodiesterase hsa00600; hsa01100; hsa04071; hsa04142; hsa04217 NA 89.5%
10 ADRB2 P07550 Beta-2 adrenergic receptor hsa04020; hsa04022; hsa04024; hsa04080; hsa04261; hsa04923; hsa04924; hsa04970 1GQ4; 2R4R; 2R4S; 2RH1; 3D4S; 3KJ6; 3NY8; 3NY9; 3NYA; 3P0G; 3PDS; 3SN6; 4GBR; 4LDE; 4LDL; 4LDO; 4QKX 88.8%
11 SIGMAR1 Q99720 Sigma non-opioid intracellular receptor 1 NA NA 88.3%
12 HTR4 Q13639 5-hydroxytryptamine receptor 4 hsa04020; hsa04024; hsa04080; hsa04726 NA 87.8%
13 KCNH2 Q12809 Potassium voltage-gated channel subfamily H member 2 NA 1BYW; 1UJL; 2L0W; 2L1M; 2L4R; 2LE7; 4HP9; 4HQA 85.7%
14 SLC18A2 Q05940 Synaptic vesicular amine transporter hsa04721; hsa04726; hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA 85.2%
15 CALY Q9NYX4 Neuron-specific vesicular protein calcyon hsa04728 NA 84.0%
16 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 NA NA 82.5%
17 KCND2 Q9NZV8 Potassium voltage-gated channel subfamily D member 2 hsa04726 NA 81.8%
18 KCND3 Q9UK17 Potassium voltage-gated channel subfamily D member 3 NA 1S1G; 2NZ0 79.8%
19 HRH3 Q9Y5N1 Histamine H3 receptor hsa04080 NA 79.8%
20 ORM2 P19652 Alpha-1-acid glycoprotein 2 NA 3APU; 3APV; 3APW; 3APX 79.5%


96 known interactions (drugs) of input target (ADRA2A): Alpha-2A adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB01018 Guanfacine Thumb
3 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
4 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB01200 Bromocriptine Thumb
6 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
7 Approved;
Investigational
SmallMoleculeDrug DB00751 Epinastine Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB00935 Oxymetazoline Thumb
9 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
10 Approved;
Investigational
SmallMoleculeDrug DB09242 Moxonidine Thumb
11 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
12 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
13 Approved;
Investigational
SmallMoleculeDrug DB00734 Risperidone Thumb
14 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
15 Approved;
Investigational
SmallMoleculeDrug DB09205 Moxisylyte Thumb
16 Experimental;
Illicit
SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
17 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb
18 Approved;
Nutraceutical;
Withdrawn
SmallMoleculeDrug DB01363 Ephedra Thumb
19 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb
20 Vet approved SmallMoleculeDrug DB11477 Xylazine Thumb
21 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
22 Approved;
Investigational
SmallMoleculeDrug DB04846 Celiprolol Thumb
23 Approved;
Investigational
SmallMoleculeDrug DB00656 Trazodone Thumb
24 Approved;
Investigational
SmallMoleculeDrug DB06623 Flupirtine Thumb
25 Approved SmallMoleculeDrug DB00692 Phentolamine Thumb
26 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb
27 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
28 Approved;
Illicit
SmallMoleculeDrug DB00865 Benzphetamine Thumb
29 Approved;
Investigational
SmallMoleculeDrug DB00268 Ropinirole Thumb
30 Approved;
Investigational
SmallMoleculeDrug DB00320 Dihydroergotamine Thumb
31 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb
32 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb
33 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
34 Approved;
Investigational
SmallMoleculeDrug DB01608 Propericiazine Thumb
35 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb
36 Approved;
Investigational
SmallMoleculeDrug DB09229 Aranidipine Thumb
37 Approved;
Investigational
SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
38 Approved SmallMoleculeDrug DB06707 Levonordefrin Thumb
39 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
40 Approved;
Investigational
SmallMoleculeDrug DB04948 Lofexidine Thumb
41 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
42 Approved SmallMoleculeDrug DB06711 Naphazoline Thumb
43 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
44 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb
45 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
46 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
47 Approved;
Investigational
SmallMoleculeDrug DB00714 Apomorphine Thumb
48 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
49 Approved;
Vet approved;
Withdrawn
SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb
50 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
51 Approved;
Withdrawn
SmallMoleculeDrug DB01149 Nefazodone Thumb
52 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb
53 Approved;
Investigational
SmallMoleculeDrug DB09286 Pipamperone Thumb
54 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
55 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
56 Approved SmallMoleculeDrug DB00964 Apraclonidine Thumb
57 Approved SmallMoleculeDrug DB00968 Methyldopa Thumb
58 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
59 Experimental SmallMoleculeDrug DB09202 Cirazoline Thumb
60 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
61 Approved SmallMoleculeDrug DB00575 Clonidine Thumb
62 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
63 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
64 Approved;
Investigational
SmallMoleculeDrug DB00697 Tizanidine Thumb
65 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb
66 Approved;
Investigational
SmallMoleculeDrug DB00413 Pramipexole Thumb
67 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
68 Approved;
Investigational
SmallMoleculeDrug DB00934 Maprotiline Thumb
69 Approved;
Investigational
SmallMoleculeDrug DB11738 Rilmenidine Thumb
70 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
71 Approved;
Investigational
SmallMoleculeDrug DB00589 Lisuride Thumb
72 Approved;
Vet approved
SmallMoleculeDrug DB00668 Epinephrine Thumb
73 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
74 Approved;
Experimental
SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
75 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
76 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
77 Approved;
Investigational
SmallMoleculeDrug DB06694 Xylometazoline Thumb
78 Approved;
Investigational
SmallMoleculeDrug DB13025 Tiapride Thumb
79 Approved;
Investigational
SmallMoleculeDrug DB08815 Lurasidone Thumb
80 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB00182 Amphetamine Thumb
81 Approved;
Investigational
SmallMoleculeDrug DB00629 Guanabenz Thumb
82 Approved SmallMoleculeDrug DB00484 Brimonidine Thumb
83 Approved;
Vet approved
SmallMoleculeDrug DB00797 Tolazoline Thumb
84 Approved;
Vet approved
SmallMoleculeDrug DB00633 Dexmedetomidine Thumb
85 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb
86 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
87 Approved;
Investigational
SmallMoleculeDrug DB01136 Carvedilol Thumb
88 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
89 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
90 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
91 Approved;
Investigational;
Vet approved;
Withdrawn
SmallMoleculeDrug DB01186 Pergolide Thumb
92 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
93 Approved;
Illicit
SmallMoleculeDrug DB01577 Methamphetamine Thumb
94 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
95 Approved;
Investigational
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
96 Approved;
Investigational
SmallMoleculeDrug DB06262 Droxidopa Thumb


20 predicted interactions (drugs) of input target (ADRA2A): Alpha-2A adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 95.2%
2 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 94.9%
3 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 94.9%
4 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB06144 Sertindole Thumb 94.8%
5 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb 94.8%
6 Approved;
Investigational
SmallMoleculeDrug DB09128 Brexpiprazole Thumb 94.7%
7 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 94.7%
8 Approved;
Vet approved
SmallMoleculeDrug DB01614 Acepromazine Thumb 94.4%
9 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 94.4%
10 Approved;
Vet approved
SmallMoleculeDrug DB00420 Promazine Thumb 94.4%
11 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 94.4%
12 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 94.3%
13 Approved;
Withdrawn
SmallMoleculeDrug DB00679 Thioridazine Thumb 94.2%
14 Approved;
Investigational
SmallMoleculeDrug DB09068 Vortioxetine Thumb 94.2%
15 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb 93.8%
16 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB09225 Zotepine Thumb 93.7%
17 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB00875 Flupentixol Thumb 93.6%
18 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 93.4%
19 Approved SmallMoleculeDrug DB00247 Methysergide Thumb 93.2%
20 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB01239 Chlorprothixene Thumb 93.1%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.