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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: yes
Input target 1: 5HT7R
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR7 P34969 5-hydroxytryptamine receptor 7 hsa04014; hsa04020; hsa04080; hsa04726 NA


37 known interactions (drugs) of input target (HTR7): 5-hydroxytryptamine receptor 7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB00589 Lisuride Thumb
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
4 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB00216 Eletriptan Thumb
6 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
7 Approved;
Experimental
SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
8 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
9 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
10 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
11 Approved;
Investigational
SmallMoleculeDrug DB06148 Mianserin Thumb
12 Approved;
Investigational
SmallMoleculeDrug DB06288 Amisulpride Thumb
13 Approved;
Investigational
SmallMoleculeDrug DB13025 Tiapride Thumb
14 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
15 Approved;
Investigational
SmallMoleculeDrug DB08815 Lurasidone Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB00751 Epinastine Thumb
17 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
18 Investigational SmallMoleculeDrug DB13988 SB-269970 Thumb
19 Approved;
Investigational
SmallMoleculeDrug DB09068 Vortioxetine Thumb
20 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
21 Approved;
Investigational
SmallMoleculeDrug DB01238 Aripiprazole Thumb
22 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
23 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
24 Approved;
Investigational
SmallMoleculeDrug DB00734 Risperidone Thumb
25 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
26 Approved;
Investigational
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
27 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB09225 Zotepine Thumb
28 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
29 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
30 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
31 Approved;
Investigational
SmallMoleculeDrug DB01200 Bromocriptine Thumb
32 Approved;
Investigational
SmallMoleculeDrug DB04948 Lofexidine Thumb
33 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
34 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb
35 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb
36 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
37 Approved;
Investigational
SmallMoleculeDrug DB00934 Maprotiline Thumb


20 predicted interactions (drugs) of input target (HTR7): 5-hydroxytryptamine receptor 7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 95.7%
2 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 95.6%
3 Approved;
Investigational
SmallMoleculeDrug DB01151 Desipramine Thumb 95.3%
4 Approved;
Investigational
SmallMoleculeDrug DB01142 Doxepin Thumb 95.2%
5 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 95.1%
6 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 95.0%
7 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 94.9%
8 Approved;
Investigational
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 94.9%
9 Approved;
Investigational
SmallMoleculeDrug DB00714 Apomorphine Thumb 94.8%
10 Approved;
Investigational;
Vet approved;
Withdrawn
SmallMoleculeDrug DB01186 Pergolide Thumb 94.7%
11 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb 94.7%
12 Approved;
Investigational
SmallMoleculeDrug DB00413 Pramipexole Thumb 94.6%
13 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 94.6%
14 Approved;
Investigational
SmallMoleculeDrug DB00268 Ropinirole Thumb 94.6%
15 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 94.4%
16 Approved;
Vet approved
SmallMoleculeDrug DB00420 Promazine Thumb 94.4%
17 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 94.4%
18 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb 94.3%
19 Approved;
Investigational
SmallMoleculeDrug DB00656 Trazodone Thumb 94.3%
20 Approved;
Investigational
SmallMoleculeDrug DB09286 Pipamperone Thumb 94.3%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.