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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB04864


2 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.044 0.015
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.089 0.015


37 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRM2;OPRD1;OPRM1;CHRM4;HTR1A;CHRNA2;CHRM1;OPRK1;CCKBR;CHRM3 10 0.27 2.4E-9
2 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;SLC6A4;HTR1A;MAOB 4 0.15 0.002
3 hsa00910 Nitrogen metabolism Metabolism Energy metabolism CA2;CA1 2 0.076 0.0048
4 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM3;CCKBR;CHRM1;CHRM2 4 0.19 0.0048
5 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;CHRM3;HTR1A 3 0.12 0.005
6 hsa04971 Gastric acid secretion Organismal Systems Digestive system CA2;CHRM3;CCKBR 3 0.12 0.006
7 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM4;CHRM1;CHRM2 4 0.13 0.006
8 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1;HTR1A 3 0.19 0.044
9 hsa04972 Pancreatic secretion Organismal Systems Digestive system CA2;CHRM3 2 0.12 0.081
10 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism MAOB 1 0.1 0.14
11 hsa00340 Histidine metabolism Metabolism Amino acid metabolism MAOB 1 0.13 0.16
12 hsa04964 Proximal tubule bicarbonate reclamation Organismal Systems Excretory system CA2 1 0.076 0.16
13 hsa04966 Collecting duct acid secretion Organismal Systems Excretory system CA2 1 0.081 0.16
14 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins AKR1B1 1 0.077 0.16
15 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism MAOB 1 0.093 0.16
16 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism MAOB 1 0.088 0.16
17 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism MAOB 1 0.076 0.16
18 hsa00040 Pentose and glucuronate interconversions Metabolism Carbohydrate metabolism AKR1B1 1 0.21 0.16
19 hsa00051 Fructose and mannose metabolism Metabolism Carbohydrate metabolism AKR1B1 1 0.11 0.16
20 hsa00052 Galactose metabolism Metabolism Carbohydrate metabolism AKR1B1 1 0.11 0.17
21 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism MAOB 1 0.093 0.18
22 hsa05030 Cocaine addiction Human Diseases Substance dependence MAOB 1 0.13 0.18
23 hsa00561 Glycerolipid metabolism Metabolism Lipid metabolism AKR1B1 1 0.17 0.21
24 hsa04976 Bile secretion Organismal Systems Digestive system CA2 1 0.11 0.22
25 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism MAOB 1 0.078 0.22
26 hsa05031 Amphetamine addiction Human Diseases Substance dependence MAOB 1 0.13 0.22
27 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism CES1 1 0.076 0.23
28 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1 2 0.19 0.23
29 hsa05032 Morphine addiction Human Diseases Substance dependence OPRM1 1 0.12 0.23
30 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3 1 0.12 0.23
31 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.11 0.23
32 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.13 0.27
33 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAOB 1 0.14 0.29
34 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system OPRM1 1 0.14 0.29
35 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.14 0.33
36 hsa05034 Alcoholism Human Diseases Substance dependence MAOB 1 0.12 0.35
37 hsa01100 Metabolic pathways Metabolism Global and overview maps MAOB;AKR1B1;CES1 3 0.27 0.58


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.