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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00675


98 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system PRKCG;PRKCE;PRKCD;PRKCQ;PRKCA;PRKCB 6 0.11 4.0E-7
2 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PRKCG;PRKCE;PRKCD;PRKCQ;PRKCA;PRKCB 6 0.12 6.7E-7
3 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system PRKCD;PRKCG;PRKCE;PRKCA;PRKCB 5 0.28 5.8E-6
4 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases PRKCD;PRKCE;PRKCZ;PRKCA;PRKCB 5 0.12 6.7E-6
5 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PRKCD;PRKCQ;PRKCE;PRKCZ;PRKCB 5 0.12 7.9E-6
6 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCE;PRKCZ;PRKCA;PRKCB 5 0.12 9.2E-6
7 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1;PRKCG;PRKCA;PRKCB 4 0.16 9.2E-6
8 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCZ;PRKCA;PRKCB;PRKCI 5 0.12 0.00013
9 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system PRKCG;PRKCE;PRKCA;PRKCB 4 0.17 0.00013
10 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic PRKCG;PRKCA;PRKCB 3 0.31 0.0002
11 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;PRKCG;PRKCA;PRKCB 4 0.12 0.0002
12 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system PRKCG;PRKCA;PRKCB 3 0.26 0.0002
13 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases PRKCD;PRKCE;PRKCZ 3 0.15 0.00035
14 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PRKCG;ESR2;AR;PRKCA;ESR1;PRKCB 6 0.25 0.00053
15 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.13 0.00063
16 hsa04730 Long-term depression Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.2 0.00063
17 hsa05031 Amphetamine addiction Human Diseases Substance dependence PRKCG;PRKCA;PRKCB 3 0.12 0.00077
18 hsa04720 Long-term potentiation Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.15 0.00077
19 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types PRKCG;PRKCA;PRKCB 3 0.19 0.00078
20 hsa05214 Glioma Human Diseases Cancers: Specific types PRKCG;PRKCA;PRKCB 3 0.22 0.00083
21 hsa04971 Gastric acid secretion Organismal Systems Digestive system PRKCG;PRKCA;PRKCB 3 0.13 0.00089
22 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system PRKCG;PRKCA;PRKCB 3 0.26 0.00089
23 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;PRKCG;PRKCA;PRKCB 4 0.13 0.00091
24 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic PRKCG;PRKCA;PRKCB 3 0.13 0.00095
25 hsa04911 Insulin secretion Organismal Systems Endocrine system PRKCG;PRKCA;PRKCB 3 0.13 0.0011
26 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.14 0.0011
27 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes PRKCG;PRKCA;PRKCB 3 0.12 0.0011
28 hsa04727 GABAergic synapse Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.13 0.0011
29 hsa05032 Morphine addiction Human Diseases Substance dependence PRKCG;PRKCA;PRKCB 3 0.11 0.0012
30 hsa04970 Salivary secretion Organismal Systems Digestive system PRKCG;PRKCA;PRKCB 3 0.12 0.0012
31 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system PRKCD;PRKCA;PRKCB 3 0.13 0.0012
32 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic PRKCG;PRKCA;PRKCB 3 0.14 0.0012
33 hsa04972 Pancreatic secretion Organismal Systems Digestive system PRKCG;PRKCA;PRKCB 3 0.12 0.0012
34 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation PRKCG;PRKCA;PRKCB 3 0.13 0.0012
35 hsa04070 Phosphatidylinositol signaling system Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.37 0.0012
36 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PRKCG;PRKCA;PRKCB 3 0.19 0.0012
37 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.12 0.0012
38 hsa04916 Melanogenesis Organismal Systems Endocrine system PRKCG;PRKCA;PRKCB 3 0.24 0.0012
39 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PRKCG;PRKCA;PRKCB 3 0.13 0.0014
40 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system PRKCG;PRKCA;PRKCB 3 0.26 0.0016
41 hsa04725 Cholinergic synapse Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.11 0.0016
42 hsa04724 Glutamatergic synapse Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.14 0.0016
43 hsa04726 Serotonergic synapse Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.14 0.0016
44 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PRKCG;PRKCE;PRKCA;PRKCB 4 0.11 0.0021
45 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system PRKCG;PRKCA;PRKCB 3 0.16 0.0022
46 hsa04728 Dopaminergic synapse Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.12 0.0022
47 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;PRKCD;ESR2 3 0.13 0.0025
48 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral PRKCG;PRKCA;PRKCB 3 0.11 0.0028
49 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.21 0.0028
50 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PRKCG;PRKCA;PRKCB 3 0.11 0.0029
51 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PRKCG;PRKCA;PRKCB 3 0.12 0.003
52 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.16 0.003
53 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types PRKCG;PRKCA;PRKCB 3 0.13 0.0039
54 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes PRKCE;PRKCZ;PRKCI 3 0.15 0.004
55 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.19 0.0048
56 hsa04062 Chemokine signaling pathway Organismal Systems Immune system PRKCD;PRKCZ;PRKCB 3 0.13 0.0052
57 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes PRKCG;PRKCA;PRKCB 3 0.12 0.0059
58 hsa05170 Human immunodeficiency virus 1 infection 0 0 PRKCG;PRKCA;PRKCB 3 0.12 0.0069
59 hsa05163 Human cytomegalovirus infection 0 0 PRKCG;PRKCA;PRKCB 3 0.12 0.0081
60 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.11 0.0086
61 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.12 0.0086
62 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PRKCQ;PRKCB 2 0.13 0.015
63 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;ESR2 2 0.11 0.016
64 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction PRKCG;PRKCA;PRKCB 3 0.12 0.016
65 hsa04611 Platelet activation Organismal Systems Immune system PRKCZ;PRKCI 2 0.11 0.024
66 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism PRKCD;PRKCQ 2 0.15 0.026
67 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system PRKCZ;PRKCA 2 0.12 0.026
68 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PRKCZ;PRKCI 2 0.12 0.028
69 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;ESR2 2 0.12 0.032
70 hsa04390 Hippo signaling pathway Environmental Information Processing Signal transduction PRKCZ;PRKCI 2 0.41 0.034
71 hsa05164 Influenza A Human Diseases Infectious diseases: Viral PRKCA;PRKCB 2 0.12 0.041
72 hsa00100 Steroid biosynthesis Metabolism Lipid metabolism EBP 1 0.37 0.041
73 hsa04360 Axon guidance Organismal Systems Development PRKCZ;PRKCA 2 0.18 0.041
74 hsa04144 Endocytosis Cellular Processes Transport and catabolism PRKCZ;PRKCI 2 0.21 0.075
75 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system PRKCB 1 0.31 0.089
76 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial PRKCA 1 0.34 0.1
77 hsa05130 Pathogenic Escherichia coli infection Human Diseases Infectious diseases: Bacterial PRKCA 1 0.33 0.11
78 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PRKCZ;PRKCI 2 0.13 0.13
79 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system PRKCA 1 0.14 0.13
80 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PRKCQ 1 0.17 0.13
81 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system PRKCB 1 0.24 0.13
82 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PRKCB 1 0.13 0.13
83 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system PRKCQ 1 0.17 0.16
84 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.12 0.17
85 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system PRKCQ 1 0.13 0.17
86 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PRKCD 1 0.12 0.18
87 hsa04659 Th17 cell differentiation Organismal Systems Immune system PRKCQ 1 0.13 0.18
88 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system PRKCD 1 0.13 0.2
89 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death AR 1 0.12 0.2
90 hsa05162 Measles Human Diseases Infectious diseases: Viral PRKCQ 1 0.12 0.21
91 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction PRKCE 1 0.13 0.21
92 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases PRKCZ 1 0.12 0.22
93 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system PRKCA 1 0.12 0.22
94 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.14 0.22
95 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction PRKCE 1 0.13 0.24
96 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system PRKCD 1 0.13 0.24
97 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.17 0.45
98 hsa01100 Metabolic pathways Metabolism Global and overview maps EBP 1 0.27 0.9


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.