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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07150


6 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types NCOA1;ESR2 2 0.17 0.0012
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NCOA1;ESR2 2 0.14 0.0012
3 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NCOA1;ESR2 2 0.25 0.0099
4 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR2 1 0.24 0.028
5 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR2 1 0.14 0.031
6 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system NCOA1 1 0.14 0.031


52 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;AR;CDK2 3 0.12 0.091
2 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;CYP1B1 2 0.13 0.11
3 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PIM1;PPARD 2 0.15 0.12
4 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA;PPARD 2 0.2 0.12
5 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR;CDK2 2 0.11 0.14
6 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;PTPN1 2 0.11 0.14
7 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;ALOX5 2 0.14 0.14
8 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR;CDK2 2 0.13 0.14
9 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PRKCI;PTPN1 2 0.13 0.17
10 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series Metabolism Glycan biosynthesis and metabolism ABO 1 0.19 0.28
11 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CD19;CDK2 2 0.11 0.28
12 hsa05340 Primary immunodeficiency Human Diseases Immune diseases CD19 1 0.27 0.31
13 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.22 0.31
14 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CD19;CDK2 2 0.17 0.31
15 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.14 0.31
16 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.23 0.32
17 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral CDK2;PRKCI 2 0.13 0.32
18 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CDK2 1 0.12 0.32
19 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.12 0.32
20 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases PIM1 1 0.12 0.33
21 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system CD19 1 0.17 0.33
22 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.13 0.33
23 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types CDK2 1 0.11 0.33
24 hsa04218 Cellular senescence Cellular Processes Cell growth and death CDK2 1 0.11 0.33
25 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction PIM1 1 0.12 0.33
26 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CDK2 1 0.11 0.33
27 hsa04390 Hippo signaling pathway Environmental Information Processing Signal transduction PRKCI 1 0.26 0.33
28 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system CD19 1 0.22 0.34
29 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.14 0.34
30 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes PRKCI 1 0.13 0.34
31 hsa05162 Measles Human Diseases Infectious diseases: Viral CDK2 1 0.12 0.34
32 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction CDK2 1 0.11 0.34
33 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.12 0.34
34 hsa05226 Gastric cancer Human Diseases Cancers: Specific types CDK2 1 0.11 0.34
35 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.13 0.34
36 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.16 0.35
37 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.17 0.35
38 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.12 0.35
39 hsa04110 Cell cycle Cellular Processes Cell growth and death CDK2 1 0.12 0.35
40 hsa04611 Platelet activation Organismal Systems Immune system PRKCI 1 0.11 0.35
41 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CDK2 1 0.11 0.35
42 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CDK2 1 0.12 0.35
43 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.12 0.36
44 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction PRKCI 1 0.12 0.36
45 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CDK2 1 0.11 0.36
46 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.36
47 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.18 0.36
48 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PIM1;CYP1B1 2 0.11 0.37
49 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism ALOX5 1 0.12 0.37
50 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism CYP1B1 1 0.22 0.39
51 hsa04144 Endocytosis Cellular Processes Transport and catabolism PRKCI 1 0.18 0.4
52 hsa01100 Metabolic pathways Metabolism Global and overview maps ABO;ALOX5 2 0.27 0.76


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.