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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB14011


36 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction OPRD1;OPRM1;GLRA1;CNR2;TRPV1;HTR1A;GLRA3;HTR2A;GLRB;CNR1 10 0.27 2.0E-8
2 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system TRPM8;TRPV4;TRPV3;TRPV1;HTR2A;TRPV2;TRPA1 7 0.13 7.0E-8
3 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CACNA1H;CACNA1I;VDAC1;HTR2A;CACNA1G 5 0.19 0.0012
4 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1H;CACNA1I;CACNA1G 3 0.3 0.0055
5 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1H;CACNA1I;CACNA1G 3 0.24 0.012
6 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1H;CACNA1I;CACNA1G 3 0.21 0.012
7 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1H;CACNA1I;CACNA1G 3 0.15 0.039
8 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR1A;HTR2A 2 0.15 0.17
9 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA1H;CACNA1I;CACNA1G 3 0.14 0.17
10 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TRPV2;VDAC1 2 0.16 0.22
11 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction OPRD1;VDAC1 2 0.14 0.22
12 hsa04218 Cellular senescence Cellular Processes Cell growth and death VDAC1;TRPV4 2 0.14 0.23
13 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG;VDAC1 2 0.2 0.24
14 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.36 0.24
15 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CNR1;PPARG 2 0.21 0.27
16 hsa04979 Cholesterol metabolism Organismal Systems Digestive system VDAC1 1 0.3 0.27
17 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1G 1 0.2 0.28
18 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.22 0.36
19 hsa05032 Morphine addiction Human Diseases Substance dependence OPRM1 1 0.14 0.36
20 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARG 1 0.28 0.36
21 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes HTR2A 1 0.13 0.37
22 hsa04742 Taste transduction Organismal Systems Sensory system HTR1A 1 0.14 0.38
23 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases VDAC1 1 0.17 0.41
24 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CNR1 1 0.13 0.41
25 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases TRPV4 1 0.13 0.41
26 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.16 0.42
27 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.15 0.42
28 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system OPRM1 1 0.14 0.42
29 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.14 0.42
30 hsa04217 Necroptosis Cellular Processes Cell growth and death VDAC1 1 0.18 0.43
31 hsa05164 Influenza A Human Diseases Infectious diseases: Viral VDAC1 1 0.13 0.43
32 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG 1 0.19 0.45
33 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1A 1 0.19 0.45
34 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction CNR1 1 0.14 0.45
35 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral VDAC1 1 0.15 0.52
36 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARG 1 0.26 0.77


19 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD5;DRD3;DRD4;CACNA1A;DRD2;SLC6A3 6 0.12 1.1E-5
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM3;CHRM4;CACNA1A;CHRM1;CHRM5 5 0.11 6.5E-5
3 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM4;CHRM1;CHRM5 4 0.11 0.011
4 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD2;SLC6A3 2 0.13 0.032
5 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3 1 0.13 0.26
6 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.11 0.26
7 hsa04727 GABAergic synapse Organismal Systems Nervous system CACNA1A 1 0.16 0.26
8 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.19 0.27
9 hsa04924 Renin secretion Organismal Systems Endocrine system ADORA1 1 0.15 0.28
10 hsa05031 Amphetamine addiction Human Diseases Substance dependence SLC6A3 1 0.13 0.28
11 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3 1 0.17 0.28
12 hsa04724 Glutamatergic synapse Organismal Systems Nervous system CACNA1A 1 0.19 0.28
13 hsa05034 Alcoholism Human Diseases Substance dependence DRD2;SLC6A3 2 0.12 0.29
14 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system CACNA1A 1 0.18 0.29
15 hsa05033 Nicotine addiction Human Diseases Substance dependence CACNA1A 1 0.23 0.31
16 hsa04730 Long-term depression Organismal Systems Nervous system CACNA1A 1 0.3 0.31
17 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADORA1 1 0.14 0.34
18 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.11 0.48
19 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM1 1 0.17 0.6


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.