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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB08167


2 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.044 0.015
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.089 0.015


39 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA1A;DRD2;CHRNA2;DRD1;HTR2A;HTR6;CHRNA4 7 0.27 9.6E-6
2 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;SLC6A4;SLC18A2;HTR2A;HTR6 5 0.15 2.8E-5
3 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD1;SLC18A2;DRD2 3 0.18 0.0012
4 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction ADRA1A;DRD1;HTR2A;HTR6 4 0.2 0.0028
5 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD1;DRD2;HTR2A 3 0.14 0.0041
6 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD1;SLC18A2;DRD2 3 0.15 0.011
7 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD1;SLC18A2;DRD2 3 0.22 0.012
8 hsa05034 Alcoholism Human Diseases Substance dependence DRD1;SLC18A2;DRD2 3 0.15 0.02
9 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR6;DRD1;DRD2 3 0.2 0.023
10 hsa05031 Amphetamine addiction Human Diseases Substance dependence DRD1;SLC18A2 2 0.19 0.027
11 hsa00670 One carbon pool by folate Metabolism Metabolism of cofactors and vitamins SHMT1 1 0.19 0.13
12 hsa00630 Glyoxylate and dicarboxylate metabolism Metabolism Carbohydrate metabolism SHMT1 1 0.19 0.17
13 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic SHMT1 1 0.15 0.17
14 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism SHMT1 1 0.18 0.18
15 hsa05033 Nicotine addiction Human Diseases Substance dependence CHRNA4 1 0.18 0.18
16 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system NR3C2 1 0.17 0.19
17 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.18 0.19
18 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system SLC18A2 1 0.19 0.24
19 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.18 0.25
20 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2A 1 0.14 0.26
21 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.14 0.26
22 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps SHMT1 1 0.17 0.26
23 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A 1 0.15 0.26
24 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death AR 1 0.2 0.26
25 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.15 0.26
26 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.21 0.27
27 hsa05032 Morphine addiction Human Diseases Substance dependence DRD1 1 0.15 0.27
28 hsa04970 Salivary secretion Organismal Systems Digestive system ADRA1A 1 0.16 0.27
29 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A 1 0.17 0.27
30 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.15 0.27
31 hsa01200 Carbon metabolism Metabolism Global and overview maps SHMT1 1 0.15 0.27
32 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.14 0.28
33 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1 1 0.16 0.28
34 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRA1A 1 0.14 0.28
35 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.14 0.29
36 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;AR 2 0.26 0.29
37 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.15 0.33
38 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.14 0.33
39 hsa01100 Metabolic pathways Metabolism Global and overview maps SHMT1 1 0.27 0.93


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.