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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00624


11 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1 1 0.16 0.064
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.13 0.064
3 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death AR 1 0.2 0.066
4 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.15 0.067
5 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system NR3C2 1 0.22 0.069
6 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.22 0.069
7 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.14 0.071
8 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.15 0.071
9 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.17 0.077
10 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.079
11 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;AR 2 0.25 0.081


80 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD17B2;SRD5A1;HSD17B1;CYP17A1 4 0.34 0.00048
2 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD17B2;HSD17B1;CYP17A1 3 0.17 0.0056
3 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system CACNA2D3;ATP1A1;MAPK14 3 0.11 0.087
4 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system MMP9;MAPK14 2 0.24 0.21
5 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MMP9;MAPK14 2 0.13 0.21
6 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system TRPV3;MAPK14 2 0.11 0.21
7 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR;MAPK14 2 0.11 0.21
8 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases MMP9;MAPK14 2 0.11 0.23
9 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes ESRRB;MAPK14 2 0.18 0.23
10 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNA2D3;ATP1A1 2 0.29 0.23
11 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MMP9;MAPK14 2 0.11 0.25
12 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MMP9;MAPK14 2 0.12 0.25
13 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CRH;CYP17A1 2 0.12 0.26
14 hsa04964 Proximal tubule bicarbonate reclamation Organismal Systems Excretory system ATP1A1 1 0.26 0.28
15 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.14 0.34
16 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.12 0.34
17 hsa04659 Th17 cell differentiation Organismal Systems Immune system MAPK14 1 0.12 0.34
18 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic MAPK14 1 0.12 0.34
19 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.15 0.34
20 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.34
21 hsa00190 Oxidative phosphorylation Metabolism Energy metabolism MT-ATP6 1 0.56 0.34
22 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic MAPK14 1 0.14 0.35
23 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system ATP1A1 1 0.19 0.35
24 hsa04972 Pancreatic secretion Organismal Systems Digestive system ATP1A1 1 0.11 0.35
25 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases MAPK14 1 0.12 0.35
26 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAPK14 1 0.12 0.35
27 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK14 1 0.14 0.35
28 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.35
29 hsa04611 Platelet activation Organismal Systems Immune system MAPK14 1 0.11 0.35
30 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral MAPK14 1 0.12 0.35
31 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK14 1 0.14 0.35
32 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK14 1 0.18 0.35
33 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.13 0.36
34 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral MMP9 1 0.11 0.36
35 hsa04380 Osteoclast differentiation Organismal Systems Development MAPK14 1 0.12 0.36
36 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system MAPK14 1 0.11 0.36
37 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNA2D3 1 0.16 0.36
38 hsa04970 Salivary secretion Organismal Systems Digestive system ATP1A1 1 0.12 0.36
39 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNA2D3 1 0.11 0.36
40 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.12 0.36
41 hsa05164 Influenza A Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.36
42 hsa04971 Gastric acid secretion Organismal Systems Digestive system ATP1A1 1 0.14 0.37
43 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.14 0.37
44 hsa01100 Metabolic pathways Metabolism Global and overview maps HSD17B2;MT-ATP6;HSD17B1;CYP17A1 4 0.27 0.37
45 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ATP1A1 1 0.12 0.37
46 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.37
47 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MMP9 1 0.14 0.37
48 hsa04218 Cellular senescence Cellular Processes Cell growth and death MAPK14 1 0.11 0.37
49 hsa05034 Alcoholism Human Diseases Substance dependence CRH 1 0.11 0.37
50 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.11 0.37
51 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.13 0.37
52 hsa04974 Protein digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.15 0.37
53 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system ATP1A1 1 0.26 0.37
54 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.16 0.38
55 hsa04911 Insulin secretion Organismal Systems Endocrine system ATP1A1 1 0.14 0.38
56 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.17 0.38
57 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ATP1A1 1 0.18 0.38
58 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.38
59 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.11 0.38
60 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic MAPK14 1 0.14 0.38
61 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNA2D3 1 0.22 0.38
62 hsa05170 Human immunodeficiency virus 1 infection 0 0 MAPK14 1 0.12 0.38
63 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNA2D3 1 0.42 0.39
64 hsa04976 Bile secretion Organismal Systems Digestive system ATP1A1 1 0.14 0.4
65 hsa05163 Human cytomegalovirus infection 0 0 MAPK14 1 0.11 0.4
66 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.22 0.41
67 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.16 0.41
68 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system MAPK14 1 0.16 0.42
69 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MT-ATP6;MAPK14 2 0.14 0.42
70 hsa05219 Bladder cancer Human Diseases Cancers: Specific types MMP9 1 0.2 0.42
71 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.28 0.42
72 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA2D3;MAPK14 2 0.12 0.44
73 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.18 0.44
74 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases MAPK14 1 0.15 0.44
75 hsa04978 Mineral absorption Organismal Systems Digestive system ATP1A1 1 0.47 0.44
76 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CYP17A1 1 0.22 0.45
77 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction OPRK1 1 0.27 0.46
78 hsa04730 Long-term depression Organismal Systems Nervous system CRH 1 0.21 0.46
79 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.13 0.46
80 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview MMP9 1 0.11 0.48


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.