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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07053


9 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.085 0.031
2 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.087 0.031
3 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.1 0.033
4 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG 1 0.085 0.033
5 hsa04714 Thermogenesis Organismal Systems Environmental adaptation PPARG 1 0.097 0.034
6 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.1 0.036
7 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARG 1 0.12 0.036
8 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.15 0.045
9 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARG 1 0.25 0.07


44 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism CBR1;ALOX5 2 0.11 0.23
2 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.12 0.27
3 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5 1 0.15 0.27
4 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system SREBF1 1 0.12 0.27
5 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system OPRM1 1 0.13 0.27
6 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system TLR9 1 0.11 0.27
7 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.12 0.27
8 hsa01100 Metabolic pathways Metabolism Global and overview maps CBR1;AMY2A;ALOX5;DHODH 4 0.27 0.27
9 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.11 0.28
10 hsa05162 Measles Human Diseases Infectious diseases: Viral TLR9 1 0.1 0.28
11 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.15 0.28
12 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5 1 0.13 0.28
13 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic TLR9 1 0.14 0.28
14 hsa04110 Cell cycle Cellular Processes Cell growth and death CHEK1 1 0.11 0.28
15 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic TLR9 1 0.11 0.28
16 hsa00240 Pyrimidine metabolism Metabolism Nucleotide metabolism DHODH 1 0.14 0.29
17 hsa04218 Cellular senescence Cellular Processes Cell growth and death CHEK1 1 0.11 0.29
18 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1 1 0.1 0.3
19 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction HRH1;OPRM1 2 0.27 0.3
20 hsa04911 Insulin secretion Organismal Systems Endocrine system ABCC8 1 0.11 0.3
21 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CBR1 1 0.14 0.3
22 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CHEK1 1 0.12 0.3
23 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CBR1 1 0.15 0.3
24 hsa04972 Pancreatic secretion Organismal Systems Digestive system AMY2A 1 0.1 0.3
25 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HRH1 1 0.19 0.31
26 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral TLR9 1 0.11 0.31
27 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.15 0.31
28 hsa05032 Morphine addiction Human Diseases Substance dependence OPRM1 1 0.11 0.31
29 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial TLR9 1 0.11 0.31
30 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.12 0.31
31 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.19 0.31
32 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CHEK1 1 0.11 0.31
33 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;SREBF1 2 0.1 0.31
34 hsa05170 Human immunodeficiency virus 1 infection 0 0 CHEK1 1 0.1 0.32
35 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases ABCC8 1 0.12 0.33
36 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.14 0.33
37 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC8 1 0.24 0.34
38 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system AMY2A 1 0.16 0.36
39 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral CHEK1 1 0.1 0.36
40 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA;SREBF1 2 0.11 0.39
41 hsa00620 Pyruvate metabolism Metabolism Carbohydrate metabolism GLO1 1 0.24 0.41
42 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism AMY2A 1 0.22 0.41
43 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic TLR9 1 0.19 0.45
44 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins CBR1 1 0.16 0.49


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.