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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03348


2 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.044 0.015
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.089 0.015


101 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system PDCD1;AKT2 2 0.14 0.13
2 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases AKT2;PTPN1 2 0.11 0.13
3 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction TF;AKT2 2 0.12 0.13
4 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PLD1;AKT2 2 0.14 0.13
5 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system AKT2;SCN5A 2 0.12 0.13
6 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system AKT2;PTPN1 2 0.13 0.14
7 hsa04210 Apoptosis Cellular Processes Cell growth and death AKT2;CTSB 2 0.14 0.14
8 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction PLD1;AKT2 2 0.12 0.14
9 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism AKT2;CTSB 2 0.15 0.15
10 hsa05033 Nicotine addiction Human Diseases Substance dependence CHRNB2;CHRNA4 2 0.15 0.15
11 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PLD1;AKT2 2 0.21 0.15
12 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system PLD1;AKT2 2 0.32 0.18
13 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRNA4;CHRNB2;CHRNA2 3 0.27 0.19
14 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PLD1;AKT2 2 0.18 0.22
15 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types PLD1;AKT2 2 0.16 0.22
16 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases AKT2 1 0.13 0.26
17 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.16 0.26
18 hsa05226 Gastric cancer Human Diseases Cancers: Specific types AKT2 1 0.11 0.26
19 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases AKT2 1 0.12 0.26
20 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes AKT2 1 0.18 0.26
21 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral AKT2 1 0.11 0.26
22 hsa04514 Cell adhesion molecules (CAMs) Environmental Information Processing Signaling molecules and interaction PDCD1 1 0.35 0.26
23 hsa05224 Breast cancer Human Diseases Cancers: Specific types AKT2 1 0.11 0.26
24 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.11 0.26
25 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PLD1;AKT2 2 0.26 0.26
26 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system AKT2 1 0.13 0.26
27 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.13 0.26
28 hsa05164 Influenza A Human Diseases Infectious diseases: Viral AKT2 1 0.11 0.26
29 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases BACE1 1 0.12 0.26
30 hsa05162 Measles Human Diseases Infectious diseases: Viral AKT2 1 0.12 0.26
31 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.13 0.27
32 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.15 0.27
33 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system CTSB 1 0.13 0.27
34 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types AKT2 1 0.13 0.27
35 hsa04218 Cellular senescence Cellular Processes Cell growth and death AKT2 1 0.11 0.27
36 hsa04728 Dopaminergic synapse Organismal Systems Nervous system AKT2 1 0.12 0.27
37 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral AKT2 1 0.13 0.27
38 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial AKT2 1 0.11 0.27
39 hsa04611 Platelet activation Organismal Systems Immune system AKT2 1 0.11 0.27
40 hsa04142 Lysosome Cellular Processes Transport and catabolism CTSB 1 0.37 0.27
41 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system AKT2 1 0.11 0.27
42 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PLD1 1 0.13 0.27
43 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system AKT2 1 0.13 0.27
44 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system AKT2 1 0.13 0.27
45 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.13 0.27
46 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system AKT2 1 0.11 0.27
47 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system AKT2 1 0.11 0.28
48 hsa04724 Glutamatergic synapse Organismal Systems Nervous system PLD1 1 0.14 0.28
49 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic AKT2 1 0.14 0.28
50 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.13 0.28
51 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLD1;AKT2 2 0.11 0.28
52 hsa04380 Osteoclast differentiation Organismal Systems Development AKT2 1 0.11 0.28
53 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system AKT2 1 0.15 0.28
54 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral AKT2 1 0.11 0.28
55 hsa04612 Antigen processing and presentation Organismal Systems Immune system CTSB 1 0.29 0.28
56 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic AKT2 1 0.14 0.28
57 hsa04062 Chemokine signaling pathway Organismal Systems Immune system AKT2 1 0.13 0.28
58 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types AKT2 1 0.24 0.28
59 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.14 0.28
60 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic AKT2 1 0.2 0.28
61 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic AKT2 1 0.12 0.28
62 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system AKT2 1 0.11 0.28
63 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases AKT2 1 0.11 0.28
64 hsa05218 Melanoma Human Diseases Cancers: Specific types AKT2 1 0.22 0.28
65 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview AKT2 1 0.13 0.28
66 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral AKT2 1 0.11 0.28
67 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic AKT2 1 0.11 0.29
68 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.12 0.29
69 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types AKT2 1 0.16 0.29
70 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.15 0.29
71 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes AKT2 1 0.11 0.29
72 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system PLD1 1 0.14 0.29
73 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types AKT2 1 0.11 0.29
74 hsa04211 Longevity regulating pathway Organismal Systems Aging AKT2 1 0.16 0.29
75 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AKT2 1 0.12 0.29
76 hsa05214 Glioma Human Diseases Cancers: Specific types AKT2 1 0.23 0.29
77 hsa05170 Human immunodeficiency virus 1 infection 0 0 AKT2 1 0.12 0.29
78 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system AKT2 1 0.26 0.3
79 hsa05163 Human cytomegalovirus infection 0 0 AKT2 1 0.12 0.3
80 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system AKT2 1 0.11 0.31
81 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types AKT2 1 0.32 0.31
82 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system AKT2 1 0.19 0.32
83 hsa04144 Endocytosis Cellular Processes Transport and catabolism PLD1 1 0.23 0.32
84 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system AKT2 1 0.14 0.33
85 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral AKT2 1 0.11 0.33
86 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types AKT2 1 0.21 0.33
87 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types AKT2 1 0.17 0.34
88 hsa04216 Ferroptosis Cellular Processes Cell growth and death TF 1 0.39 0.34
89 hsa04924 Renin secretion Organismal Systems Endocrine system CTSB 1 0.12 0.35
90 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system AKT2 1 0.36 0.35
91 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview AKT2 1 0.18 0.36
92 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLD1 1 0.52 0.36
93 hsa04978 Mineral absorption Organismal Systems Digestive system TF 1 0.35 0.37
94 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types AKT2 1 0.27 0.37
95 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.13 0.37
96 hsa04213 Longevity regulating pathway - multiple species Organismal Systems Aging AKT2 1 0.27 0.37
97 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system AKT2 1 0.11 0.37
98 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.12 0.37
99 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral AKT2 1 0.13 0.41
100 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction AKT2 1 0.17 0.42
101 hsa01100 Metabolic pathways Metabolism Global and overview maps PLD1 1 0.27 0.88


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.