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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07756


2 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.044 0.015
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.089 0.015


40 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction OPRD1;GABRA1;OPRM1;GLRA1;CHRNB2;CHRNA2;DRD1;OPRK1;GABRA6;CHRNA4 10 0.27 1.1E-9
2 hsa05033 Nicotine addiction Human Diseases Substance dependence GABRA1;GABRA6;CHRNB2;CHRNA4 4 0.13 2.4E-5
3 hsa05032 Morphine addiction Human Diseases Substance dependence GABRA1;DRD1;GABRA6;OPRM1 4 0.13 0.00045
4 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;GABRA1;GABRA6 3 0.13 0.0067
5 hsa05030 Cocaine addiction Human Diseases Substance dependence MAOB;DRD1 2 0.13 0.038
6 hsa05031 Amphetamine addiction Human Diseases Substance dependence MAOB;DRD1 2 0.13 0.06
7 hsa04727 GABAergic synapse Organismal Systems Nervous system GABRA1;GABRA6 2 0.14 0.085
8 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;MAOB 2 0.15 0.12
9 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAOB;DRD1 2 0.14 0.14
10 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system GABRA1;GABRA6 2 0.13 0.14
11 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism MAOB 1 0.11 0.14
12 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins AKR1B1 1 0.088 0.16
13 hsa05034 Alcoholism Human Diseases Substance dependence MAOB;DRD1 2 0.13 0.16
14 hsa00340 Histidine metabolism Metabolism Amino acid metabolism MAOB 1 0.14 0.16
15 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism MAOB 1 0.1 0.16
16 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism MAOB 1 0.093 0.16
17 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism MAOB 1 0.099 0.17
18 hsa00040 Pentose and glucuronate interconversions Metabolism Carbohydrate metabolism AKR1B1 1 0.22 0.17
19 hsa00051 Fructose and mannose metabolism Metabolism Carbohydrate metabolism AKR1B1 1 0.11 0.17
20 hsa00052 Galactose metabolism Metabolism Carbohydrate metabolism AKR1B1 1 0.11 0.17
21 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD17B1 1 0.12 0.19
22 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism MAOB 1 0.12 0.19
23 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD17B1 1 0.088 0.21
24 hsa00561 Glycerolipid metabolism Metabolism Lipid metabolism AKR1B1 1 0.18 0.21
25 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism MAOB 1 0.099 0.23
26 hsa04610 Complement and coagulation cascades Organismal Systems Immune system PLAU 1 0.13 0.24
27 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD1 1 0.13 0.26
28 hsa05215 Prostate cancer Human Diseases Cancers: Specific types PLAU 1 0.14 0.26
29 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PLAU 1 0.14 0.26
30 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.13 0.3
31 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD1 1 0.13 0.32
32 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system SCN5A 1 0.13 0.32
33 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system OPRM1 1 0.14 0.33
34 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.14 0.35
35 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction DRD1 1 0.19 0.37
36 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PLAU 1 0.14 0.37
37 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction DRD1 1 0.19 0.37
38 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview PLAU 1 0.14 0.37
39 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PLAU 1 0.13 0.49
40 hsa01100 Metabolic pathways Metabolism Global and overview maps MAOB;AKR1B1;HSD17B1 3 0.27 0.54


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.