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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00122


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PHOSPHO1;ACHE;PLD2;PCYT1A;PCYT1B;PLD1 6 0.11 7.0E-11
2 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PLD1;PLD2;PCYT1A;PCYT1B 4 0.1 3.6E-6
3 hsa00440 Phosphonate and phosphinate metabolism Metabolism Metabolism of other amino acids PCYT1A;PCYT1B 2 0.012 4.6E-5
4 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLD1;PLD2 2 0.087 0.0024
5 hsa01100 Metabolic pathways Metabolism Global and overview maps PLD1;PLD2;PHOSPHO1;PCYT1A;PCYT1B 5 0.27 0.0027
6 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system PLD1;PLD2 2 0.099 0.0054
7 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system PLD1;PLD2 2 0.11 0.0054
8 hsa04724 Glutamatergic synapse Organismal Systems Nervous system PLD1;PLD2 2 0.092 0.0061
9 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.099 0.0061
10 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PLD1;PLD2 2 0.096 0.0061
11 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.092 0.0084
12 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.2 0.014
13 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.11 0.017
14 hsa04144 Endocytosis Cellular Processes Transport and catabolism PLD1;PLD2 2 0.1 0.018
15 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types PLD1 1 0.1 0.067
16 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.11 0.092
17 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PLD1 1 0.27 0.35


40 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRNA4;GABRA5;CHRNB2;ADORA1;DRD2;GABRA6;CHRNA6;HTR1A;GABRA4;GABRA1;HTR2A;CHRNA3;CHRNB3;CNR1;CHRNA2;GABRA3 16 0.27 1.4E-18
2 hsa05033 Nicotine addiction Human Diseases Substance dependence GABRA1;CHRNA6;CHRNB2;GABRA4;GABRA5;GABRA3;GABRA6;CHRNA4 8 0.2 7.7E-13
3 hsa04742 Taste transduction Organismal Systems Sensory system GABRA5;HTR3A;HTR1A;SCN2A;GABRA4;GABRA1;GABRA6;GABRA3 8 0.14 2.5E-10
4 hsa05032 Morphine addiction Human Diseases Substance dependence GABRA1;ADORA1;GABRA4;GABRA5;GABRA6;GABRA3 6 0.14 9.4E-7
5 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system GABRA1;GABRA4;GABRA5;CNR1;GABRA6;GABRA3 6 0.13 1.3E-5
6 hsa04727 GABAergic synapse Organismal Systems Nervous system GABRA1;GABRA5;GABRA6;GABRA3;GABRA4 5 0.2 1.8E-5
7 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;HTR1A;HTR2A 3 0.14 0.019
8 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD2;HTR2A 2 0.13 0.11
9 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes MYH14;ERBB2 2 0.25 0.33
10 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR2A;ERBB2 2 0.19 0.34
11 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction CNR1;DRD2 2 0.14 0.35
12 hsa05219 Bladder cancer Human Diseases Cancers: Specific types ERBB2 1 0.5 0.35
13 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2A 1 0.14 0.35
14 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction ERBB2 1 0.17 0.35
15 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes ERBB2 1 0.2 0.36
16 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic ERBB2 1 0.31 0.36
17 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MYH14 1 0.23 0.36
18 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction ERBB2 1 0.21 0.36
19 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ERBB2 1 0.13 0.36
20 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types ERBB2 1 0.39 0.36
21 hsa04924 Renin secretion Organismal Systems Endocrine system ADORA1 1 0.17 0.36
22 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic ERBB2 1 0.19 0.37
23 hsa05215 Prostate cancer Human Diseases Cancers: Specific types ERBB2 1 0.13 0.37
24 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview ERBB2 1 0.29 0.38
25 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD2 1 0.15 0.38
26 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types ERBB2 1 0.74 0.39
27 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADORA1 1 0.17 0.39
28 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD2 1 0.13 0.43
29 hsa05224 Breast cancer Human Diseases Cancers: Specific types ERBB2 1 0.14 0.43
30 hsa05226 Gastric cancer Human Diseases Cancers: Specific types ERBB2 1 0.15 0.43
31 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD2 1 0.18 0.44
32 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADORA1 1 0.13 0.45
33 hsa05034 Alcoholism Human Diseases Substance dependence DRD2 1 0.14 0.47
34 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes ERBB2 1 0.16 0.48
35 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ERBB2 1 0.13 0.48
36 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility MYH14 1 0.13 0.49
37 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CNR1 1 0.21 0.5
38 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction ERBB2 1 0.13 0.57
39 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview ERBB2 1 0.14 0.57
40 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction ERBB2 1 0.18 0.62


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.