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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00122


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PHOSPHO1;ACHE;PLD2;PCYT1A;PCYT1B;PLD1 6 0.11 7.0E-11
2 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PLD1;PLD2;PCYT1A;PCYT1B 4 0.1 3.6E-6
3 hsa00440 Phosphonate and phosphinate metabolism Metabolism Metabolism of other amino acids PCYT1A;PCYT1B 2 0.012 4.6E-5
4 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLD1;PLD2 2 0.087 0.0024
5 hsa01100 Metabolic pathways Metabolism Global and overview maps PLD1;PLD2;PHOSPHO1;PCYT1A;PCYT1B 5 0.27 0.0027
6 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system PLD1;PLD2 2 0.099 0.0054
7 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system PLD1;PLD2 2 0.11 0.0054
8 hsa04724 Glutamatergic synapse Organismal Systems Nervous system PLD1;PLD2 2 0.092 0.0061
9 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.099 0.0061
10 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PLD1;PLD2 2 0.096 0.0061
11 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.092 0.0084
12 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.2 0.014
13 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLD1;PLD2 2 0.11 0.017
14 hsa04144 Endocytosis Cellular Processes Transport and catabolism PLD1;PLD2 2 0.1 0.018
15 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types PLD1 1 0.1 0.067
16 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.11 0.092
17 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PLD1 1 0.27 0.35


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.