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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB12445


5 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04611 Platelet activation Organismal Systems Immune system PTGS1 1 0.14 0.021
2 hsa04726 Serotonergic synapse Organismal Systems Nervous system PTGS1 1 0.17 0.021
3 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PTGS1 1 0.18 0.021
4 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS1 1 0.14 0.021
5 hsa01100 Metabolic pathways Metabolism Global and overview maps PTGS1 1 0.27 0.17


64 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA;PPARD;PPARG;FABP2 4 0.27 0.0012
2 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARD;NCOA1;PTGS2;ESR2;AR;PPARG;ESR1 7 0.25 0.0028
3 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;NCOA1;ESR2 3 0.12 0.053
4 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G2A;FABP2 2 0.22 0.053
5 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;PTGS2 2 0.19 0.057
6 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;NCOA1;ESR2 3 0.13 0.061
7 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.12 0.098
8 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;ESR2 2 0.11 0.16
9 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G2A;CALCRL 2 0.12 0.19
10 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;NCOA1 2 0.11 0.19
11 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.33 0.32
12 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.22 0.34
13 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.15 0.37
14 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.15 0.37
15 hsa04659 Th17 cell differentiation Organismal Systems Immune system AHR 1 0.14 0.38
16 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA 1 0.12 0.38
17 hsa04110 Cell cycle Cellular Processes Cell growth and death CHEK1 1 0.16 0.38
18 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death AR 1 0.13 0.38
19 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.12 0.38
20 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.14 0.38
21 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.14 0.39
22 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2 1 0.13 0.39
23 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.18 0.39
24 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.11 0.39
25 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases AHR 1 0.12 0.39
26 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.16 0.39
27 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1 1 0.11 0.39
28 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.28 0.39
29 hsa04218 Cellular senescence Cellular Processes Cell growth and death CHEK1 1 0.11 0.39
30 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.11 0.4
31 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.13 0.4
32 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.31 0.4
33 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.27 0.4
34 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G2A 1 0.11 0.41
35 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CHEK1 1 0.11 0.42
36 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.42
37 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.11 0.42
38 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG 1 0.16 0.42
39 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.16 0.42
40 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.19 0.42
41 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.18 0.43
42 hsa05170 Human immunodeficiency virus 1 infection 0 0 CHEK1 1 0.13 0.43
43 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HRH1 1 0.19 0.43
44 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.43
45 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CHEK1 1 0.17 0.43
46 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.16 0.43
47 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.2 0.43
48 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.26 0.43
49 hsa04714 Thermogenesis Organismal Systems Environmental adaptation PPARG 1 0.16 0.44
50 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLA2G2A 1 0.11 0.44
51 hsa05163 Human cytomegalovirus infection 0 0 PTGS2 1 0.12 0.44
52 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2 1 0.13 0.44
53 hsa04976 Bile secretion Organismal Systems Digestive system NR1H4 1 0.16 0.44
54 hsa04974 Protein digestion and absorption Organismal Systems Digestive system DPP4 1 0.17 0.46
55 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview PTGS2 1 0.2 0.46
56 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.26 0.46
57 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.22 0.46
58 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral CHEK1 1 0.13 0.46
59 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.17 0.47
60 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.24 0.49
61 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CALCRL;HRH1 2 0.27 0.49
62 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.14 0.49
63 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.11 0.51
64 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.13 0.55


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.