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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03742


8 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1 1 0.17 0.026
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.14 0.026
3 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.15 0.029
4 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.14 0.031
5 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.15 0.031
6 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.21 0.035
7 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.3 0.037
8 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1 1 0.25 0.07


137 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial TNF;NFKB2;C3 3 0.2 0.033
2 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic TNF;AKT1;C3 3 0.11 0.035
3 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system TNF;AKT1;NFKB2 3 0.099 0.035
4 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases AGTR1;TNF;AKT1 3 0.099 0.04
5 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral CHEK1;TNF;AKT1;NFKB2 4 0.1 0.043
6 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system HSP90AA1;PGR;AKT1 3 0.1 0.046
7 hsa04380 Osteoclast differentiation Organismal Systems Development TNF;AKT1;NFKB2 3 0.099 0.048
8 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases TNF;AKT1;HSP90AA1 3 0.11 0.054
9 hsa05215 Prostate cancer Human Diseases Cancers: Specific types HSP90AA1;AR;AKT1 3 0.12 0.061
10 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial TNF;AKT1;C3 3 0.1 0.098
11 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial TNF;C3 2 0.11 0.1
12 hsa04612 Antigen processing and presentation Organismal Systems Immune system TNF;HSP90AA1 2 0.18 0.1
13 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic TNF;C3 2 0.11 0.11
14 hsa05170 Human immunodeficiency virus 1 infection 0 0 CHEK1;TNF;AKT1 3 0.1 0.11
15 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system TNF;AKT1 2 0.11 0.11
16 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system TNF;AKT1 2 0.13 0.11
17 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview NFKB2;CHEK1;C3 3 0.1 0.12
18 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction TNF;NFKB2 2 0.11 0.14
19 hsa04657 IL-17 signaling pathway Organismal Systems Immune system TNF;HSP90AA1 2 0.1 0.14
20 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system TNF;AKT1 2 0.11 0.15
21 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system TNF;AKT1 2 0.11 0.15
22 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases TNF;AKT1 2 0.1 0.15
23 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction TNF;AKT1;NFKB2 3 0.12 0.15
24 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic TNF;AKT1 2 0.11 0.15
25 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction TNF;AKT1 2 0.11 0.15
26 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction TNF;AKT1 2 0.1 0.15
27 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;AR 2 0.1 0.16
28 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction AGTR1;AKT1 2 0.11 0.17
29 hsa04210 Apoptosis Cellular Processes Cell growth and death TNF;AKT1 2 0.11 0.17
30 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral TNF;AKT1 2 0.11 0.17
31 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases TNF;C3 2 0.24 0.17
32 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction AGTR1;AKT1 2 0.11 0.17
33 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system AGTR1;AKT1 2 0.11 0.17
34 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases TNF;AKT1 2 0.11 0.17
35 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction TNF;AKT1 2 0.12 0.17
36 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral TNF;AKT1 2 0.1 0.17
37 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction AGTR1;AKT1 2 0.12 0.18
38 hsa04217 Necroptosis Cellular Processes Cell growth and death TNF;HSP90AA1 2 0.11 0.18
39 hsa04614 Renin-angiotensin system Organismal Systems Endocrine system AGTR1 1 0.36 0.18
40 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TNF;HSP90AA1 2 0.11 0.18
41 hsa04218 Cellular senescence Cellular Processes Cell growth and death CHEK1;AKT1 2 0.1 0.18
42 hsa05164 Influenza A Human Diseases Infectious diseases: Viral TNF;AKT1 2 0.1 0.18
43 hsa05310 Asthma Human Diseases Immune diseases TNF 1 0.97 0.2
44 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic TNF 1 0.16 0.2
45 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral AKT1;C3 2 0.1 0.2
46 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral TNF;C3 2 0.1 0.2
47 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PDE4D;AKT1 2 0.18 0.21
48 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral NFKB2;AKT1 2 0.1 0.21
49 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic TNF 1 0.31 0.21
50 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system NR3C2 1 0.21 0.22
51 hsa05330 Allograft rejection Human Diseases Immune diseases TNF 1 0.68 0.22
52 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.29 0.23
53 hsa05332 Graft-versus-host disease Human Diseases Immune diseases TNF 1 0.52 0.23
54 hsa05163 Human cytomegalovirus infection 0 0 TNF;AKT1 2 0.11 0.23
55 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF 1 0.39 0.23
56 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system AKT1 1 0.26 0.23
57 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF 1 0.12 0.24
58 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system CYP1B1 1 0.12 0.25
59 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic TNF 1 0.19 0.25
60 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases TNF 1 0.11 0.25
61 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system AKT1 1 0.1 0.26
62 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types AKT1 1 0.13 0.26
63 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types AKT1 1 0.15 0.26
64 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CHEK1 1 0.11 0.26
65 hsa05218 Melanoma Human Diseases Cancers: Specific types AKT1 1 0.15 0.26
66 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic AKT1 1 0.14 0.26
67 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.19 0.26
68 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types AKT1 1 0.15 0.26
69 hsa05150 Staphylococcus aureus infection Human Diseases Infectious diseases: Bacterial C3 1 0.44 0.27
70 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.27
71 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism CYP1B1 1 0.27 0.27
72 hsa04924 Renin secretion Organismal Systems Endocrine system AGTR1 1 0.1 0.27
73 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases TNF 1 0.24 0.27
74 hsa04610 Complement and coagulation cascades Organismal Systems Immune system C3 1 0.11 0.27
75 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic AKT1 1 0.11 0.27
76 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types AKT1 1 0.12 0.27
77 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system AKT1 1 0.16 0.27
78 hsa05214 Glioma Human Diseases Cancers: Specific types AKT1 1 0.15 0.27
79 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types AKT1 1 0.099 0.27
80 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction HSP90AA1;AKT1 2 0.17 0.27
81 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system AKT1 1 0.23 0.27
82 hsa05032 Morphine addiction Human Diseases Substance dependence PDE4D 1 0.1 0.27
83 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral TNF;AKT1 2 0.12 0.27
84 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types AKT1 1 0.12 0.27
85 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types AKT1 1 0.17 0.27
86 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.17 0.27
87 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types AKT1 1 0.22 0.27
88 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview AKT1 1 0.13 0.27
89 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system TNF 1 0.15 0.27
90 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system AGTR1 1 0.14 0.27
91 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic TNF 1 0.11 0.27
92 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases TNF 1 0.11 0.27
93 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases TNF 1 0.13 0.27
94 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.27
95 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction TNF 1 0.35 0.27
96 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases TNF 1 0.15 0.27
97 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.27
98 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview AKT1 1 0.15 0.27
99 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.13 0.27
100 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system AGTR1 1 0.16 0.27
101 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism LTA4H 1 0.11 0.27
102 hsa04213 Longevity regulating pathway - multiple species Organismal Systems Aging AKT1 1 0.18 0.27
103 hsa04211 Longevity regulating pathway Organismal Systems Aging AKT1 1 0.12 0.27
104 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system AKT1 1 0.11 0.28
105 hsa04659 Th17 cell differentiation Organismal Systems Immune system HSP90AA1 1 0.11 0.28
106 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PDE4D 1 0.11 0.28
107 hsa04725 Cholinergic synapse Organismal Systems Nervous system AKT1 1 0.1 0.29
108 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system AGTR1 1 0.1 0.3
109 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.3
110 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system AKT1 1 0.11 0.3
111 hsa04110 Cell cycle Cellular Processes Cell growth and death CHEK1 1 0.11 0.3
112 hsa04611 Platelet activation Organismal Systems Immune system AKT1 1 0.1 0.3
113 hsa05162 Measles Human Diseases Infectious diseases: Viral AKT1 1 0.1 0.3
114 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.1 0.3
115 hsa04728 Dopaminergic synapse Organismal Systems Nervous system AKT1 1 0.12 0.31
116 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system TNF 1 0.12 0.31
117 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism AKT1 1 0.11 0.31
118 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system AKT1 1 0.1 0.31
119 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system AKT1 1 0.11 0.31
120 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes AKT1 1 0.14 0.31
121 hsa05226 Gastric cancer Human Diseases Cancers: Specific types AKT1 1 0.1 0.33
122 hsa04145 Phagosome Cellular Processes Transport and catabolism C3 1 0.15 0.33
123 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases AGTR1 1 0.099 0.33
124 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.34
125 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation HSP90AA1 1 0.19 0.35
126 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types AKT1 1 0.11 0.35
127 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases TNF 1 0.1 0.35
128 hsa00230 Purine metabolism Metabolism Nucleotide metabolism PDE4D 1 0.11 0.35
129 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction AGTR1 1 0.18 0.37
130 hsa04062 Chemokine signaling pathway Organismal Systems Immune system AKT1 1 0.11 0.37
131 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes AKT1 1 0.1 0.39
132 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.39
133 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.1 0.43
134 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction AGTR1 1 0.27 0.48
135 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction TNF 1 0.12 0.5
136 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP1B1 1 0.1 0.5
137 hsa01100 Metabolic pathways Metabolism Global and overview maps LTA4H 1 0.27 0.96


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.