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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00772


0 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑


48 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04657 IL-17 signaling pathway Organismal Systems Immune system HSP90AA1;CASP3 2 0.13 0.074
2 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic TOP2A;CASP3 2 0.22 0.074
3 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;CASP3 2 0.14 0.075
4 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview CASP3 1 0.13 0.2
5 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CASP3 1 0.13 0.2
6 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral CASP3 1 0.12 0.2
7 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CASP3 1 0.13 0.2
8 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CASP3 1 0.12 0.2
9 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system HSP90AA1 1 0.14 0.2
10 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases CASP3 1 0.17 0.2
11 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases CASP3 1 0.15 0.2
12 hsa04145 Phagosome Cellular Processes Transport and catabolism MARCO 1 0.22 0.2
13 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation HSP90AA1 1 0.25 0.2
14 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial CASP3 1 0.12 0.2
15 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CASP3 1 0.12 0.2
16 hsa05170 Human immunodeficiency virus 1 infection 0 0 CASP3 1 0.12 0.2
17 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system SCN5A 1 0.12 0.2
18 hsa04217 Necroptosis Cellular Processes Cell growth and death HSP90AA1 1 0.16 0.2
19 hsa05163 Human cytomegalovirus infection 0 0 CASP3 1 0.12 0.21
20 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases CASP3 1 0.14 0.21
21 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic CASP3 1 0.15 0.21
22 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.12 0.21
23 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases HSP90AA1 1 0.12 0.22
24 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction CASP3 1 0.14 0.22
25 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system HSP90AA1 1 0.13 0.22
26 hsa04210 Apoptosis Cellular Processes Cell growth and death CASP3 1 0.16 0.22
27 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system HSP90AA1 1 0.12 0.23
28 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases CASP3 1 0.12 0.23
29 hsa04659 Th17 cell differentiation Organismal Systems Immune system HSP90AA1 1 0.13 0.23
30 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system CASP3 1 0.19 0.23
31 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.31 0.24
32 hsa05215 Prostate cancer Human Diseases Cancers: Specific types HSP90AA1 1 0.13 0.25
33 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CASP3 1 0.13 0.26
34 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CASP3 1 0.12 0.26
35 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic CASP3 1 0.16 0.26
36 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types CASP3 1 0.12 0.28
37 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral CASP3 1 0.13 0.28
38 hsa05200 Pathways in cancer Human Diseases Cancers: Overview HSP90AA1;CASP3 2 0.25 0.29
39 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction HSP90AA1 1 0.17 0.29
40 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types CASP3 1 0.2 0.3
41 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial CASP3 1 0.15 0.31
42 hsa04612 Antigen processing and presentation Organismal Systems Immune system HSP90AA1 1 0.22 0.31
43 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CASP3 1 0.16 0.33
44 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial CASP3 1 0.18 0.35
45 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death CASP3 1 0.35 0.37
46 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial CASP3 1 0.23 0.37
47 hsa05416 Viral myocarditis Human Diseases Cardiovascular diseases CASP3 1 0.35 0.37
48 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases CASP3 1 0.16 0.4


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.