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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00304


10 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;PGR 2 0.17 0.0019
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;PGR 2 0.13 0.0019
3 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR 1 0.25 0.041
4 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.15 0.041
5 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.35 0.042
6 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR 1 0.13 0.044
7 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.13 0.044
8 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.2 0.047
9 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.059
10 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1 1 0.25 0.14


41 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD3B2;HSD17B2;SRD5A1;HSD17B1 4 0.18 0.00018
2 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD3B2;HSD17B2;HSD17B1 3 0.12 0.0023
3 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes ADRB1;CDK1 2 0.12 0.14
4 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ADRB1;CACNA2D2 2 0.11 0.14
5 hsa00670 One carbon pool by folate Metabolism Metabolism of cofactors and vitamins DHFR 1 0.36 0.24
6 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRB1;KCNJ8 2 0.13 0.24
7 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins DHFR 1 0.15 0.26
8 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system NR3C2 1 0.13 0.27
9 hsa05170 Human immunodeficiency virus 1 infection 0 0 CDK1;CALR 2 0.12 0.27
10 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRB1;CACNA2D2 2 0.12 0.27
11 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic DHFR 1 0.11 0.27
12 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system HSD3B2 1 0.11 0.33
13 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.13 0.33
14 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNA2D2 1 0.15 0.33
15 hsa04612 Antigen processing and presentation Organismal Systems Immune system CALR 1 0.12 0.33
16 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic CALR 1 0.13 0.33
17 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNA2D2 1 0.1 0.33
18 hsa04970 Salivary secretion Organismal Systems Digestive system ADRB1 1 0.12 0.34
19 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CDK1 1 0.11 0.35
20 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNA2D2 1 0.27 0.35
21 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB1 1 0.12 0.35
22 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system HSD3B2 1 0.12 0.36
23 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB1 1 0.13 0.36
24 hsa04110 Cell cycle Cellular Processes Cell growth and death CDK1 1 0.13 0.36
25 hsa04142 Lysosome Cellular Processes Transport and catabolism CTSF 1 0.21 0.36
26 hsa04218 Cellular senescence Cellular Processes Cell growth and death CDK1 1 0.12 0.37
27 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation CALR 1 0.13 0.37
28 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases HSD3B2 1 0.12 0.37
29 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNA2D2 1 0.12 0.37
30 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CDK1 1 0.12 0.37
31 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CDK1 1 0.12 0.37
32 hsa04145 Phagosome Cellular Processes Transport and catabolism CALR 1 0.1 0.38
33 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction ADRB1 1 0.19 0.38
34 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CDK1 1 0.12 0.38
35 hsa04210 Apoptosis Cellular Processes Cell growth and death CTSF 1 0.14 0.38
36 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ADRB1 1 0.19 0.38
37 hsa01100 Metabolic pathways Metabolism Global and overview maps HSD3B2;HSD17B2;HSD17B1;DHFR 4 0.27 0.39
38 hsa05163 Human cytomegalovirus infection 0 0 CALR 1 0.12 0.4
39 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral CALR 1 0.12 0.43
40 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRB1 1 0.27 0.44
41 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA2D2 1 0.13 0.45


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.