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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00398


85 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction KDR;BRAF;FGFR1;FLT3;RAF1;KIT;FLT1;FLT4;PDGFRB 9 0.13 1.7E-10
2 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction KDR;BRAF;FGFR1;RAF1;KIT;FLT1;FLT4;PDGFRB 8 0.12 5.3E-10
3 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction KDR;FGFR1;FLT3;RAF1;KIT;FLT1;FLT4;PDGFRB 8 0.12 9.3E-10
4 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview RET;FGFR1;FLT3;RAF1;KIT;PDGFRB 6 0.19 1.5E-9
5 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction KDR;FGFR1;FLT3;RAF1;KIT;FLT1;FLT4;PDGFRB 8 0.17 1.7E-8
6 hsa05200 Pathways in cancer Human Diseases Cancers: Overview BRAF;RET;FGFR1;FLT3;RAF1;KIT;FLT4;PDGFRB 8 0.25 3.2E-7
7 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes KDR;BRAF;RAF1;FLT1;FLT4;PDGFRB 6 0.12 7.7E-7
8 hsa05224 Breast cancer Human Diseases Cancers: Specific types FLT4;BRAF;RAF1;KIT;FGFR1 5 0.12 6.8E-6
9 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types BRAF;FLT3;RAF1;KIT 4 0.17 1.1E-5
10 hsa05218 Melanoma Human Diseases Cancers: Specific types BRAF;PDGFRB;RAF1;FGFR1 4 0.24 1.4E-5
11 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic BRAF;KDR;PDGFRB;RAF1 4 0.14 1.8E-5
12 hsa05215 Prostate cancer Human Diseases Cancers: Specific types BRAF;PDGFRB;RAF1;FGFR1 4 0.13 3.7E-5
13 hsa05214 Glioma Human Diseases Cancers: Specific types BRAF;PDGFRB;RAF1 3 0.34 0.00057
14 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview BRAF;KDR;RAF1;FGFR1 4 0.13 0.00057
15 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility BRAF;PDGFRB;RAF1;FGFR1 4 0.12 0.00067
16 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system BRAF;RAF1;FGFR1 3 0.13 0.0016
17 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PDGFRB;RAF1;KIT 3 0.14 0.004
18 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types BRAF;RET 2 0.53 0.0049
19 hsa05219 Bladder cancer Human Diseases Cancers: Specific types BRAF;RAF1 2 0.23 0.0058
20 hsa04730 Long-term depression Organismal Systems Nervous system BRAF;RAF1 2 0.28 0.011
21 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction KDR;RAF1 2 0.13 0.011
22 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types BRAF;RAF1 2 0.64 0.011
23 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types BRAF;RAF1 2 0.22 0.012
24 hsa04720 Long-term potentiation Organismal Systems Nervous system BRAF;RAF1 2 0.15 0.012
25 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types BRAF;RAF1 2 0.85 0.012
26 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types BRAF;RAF1 2 0.36 0.014
27 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types BRAF;RAF1 2 0.15 0.014
28 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction BRAF;RAF1 2 0.15 0.016
29 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types BRAF;RAF1 2 0.17 0.016
30 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes PDGFRB;RAF1 2 0.12 0.016
31 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PDGFRB;RAF1 2 0.26 0.018
32 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system BRAF;RAF1 2 0.12 0.018
33 hsa04916 Melanogenesis Organismal Systems Endocrine system RAF1;KIT 2 0.45 0.018
34 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic BRAF;RAF1 2 0.11 0.019
35 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system FLT3;KIT 2 0.31 0.019
36 hsa04726 Serotonergic synapse Organismal Systems Nervous system BRAF;RAF1 2 0.14 0.023
37 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system BRAF;RAF1 2 0.13 0.024
38 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system BRAF;RAF1 2 0.12 0.024
39 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral BRAF;RAF1 2 0.13 0.026
40 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction BRAF;RAF1 2 0.12 0.026
41 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system BRAF;RAF1 2 0.16 0.027
42 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system BRAF;RAF1 2 0.13 0.028
43 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes RAF1;FGFR1 2 0.19 0.028
44 hsa05226 Gastric cancer Human Diseases Cancers: Specific types BRAF;RAF1 2 0.12 0.031
45 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction BRAF;RAF1 2 0.15 0.031
46 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction PDGFRB;RAF1 2 0.15 0.035
47 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types BRAF;RAF1 2 0.13 0.036
48 hsa05034 Alcoholism Human Diseases Substance dependence BRAF;RAF1 2 0.12 0.041
49 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview FLT3;FLT1 2 0.14 0.042
50 hsa04062 Chemokine signaling pathway Organismal Systems Immune system BRAF;RAF1 2 0.14 0.043
51 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction BRAF;RAF1 2 0.18 0.046
52 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PDGFRB;RAF1 2 0.12 0.095
53 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PDGFRB;RAF1 2 0.13 0.12
54 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system RAF1 1 0.14 0.14
55 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes FGFR1 1 0.14 0.14
56 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system RAF1 1 0.4 0.14
57 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system RAF1 1 0.12 0.14
58 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases FLT1 1 0.18 0.17
59 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system RAF1 1 1 0.17
60 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system RAF1 1 0.14 0.17
61 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system RAF1 1 0.14 0.17
62 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction FLT1 1 0.13 0.17
63 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system RAF1 1 0.13 0.18
64 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system RAF1 1 0.12 0.19
65 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction RAF1 1 0.13 0.19
66 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system RAF1 1 0.12 0.2
67 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism RAF1 1 0.16 0.2
68 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system RAF1 1 0.13 0.21
69 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases KDR 1 0.12 0.21
70 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction RAF1 1 0.13 0.21
71 hsa04210 Apoptosis Cellular Processes Cell growth and death RAF1 1 0.14 0.21
72 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral RAF1 1 0.11 0.21
73 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system RAF1 1 0.12 0.22
74 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases BRAF 1 0.12 0.22
75 hsa04218 Cellular senescence Cellular Processes Cell growth and death RAF1 1 0.12 0.22
76 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction RAF1 1 0.13 0.22
77 hsa05164 Influenza A Human Diseases Infectious diseases: Viral RAF1 1 0.12 0.23
78 hsa04360 Axon guidance Organismal Systems Development RAF1 1 0.21 0.23
79 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial RAF1 1 0.12 0.23
80 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction PDGFRB 1 0.18 0.23
81 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral RAF1 1 0.12 0.23
82 hsa05170 Human immunodeficiency virus 1 infection 0 0 RAF1 1 0.13 0.26
83 hsa05163 Human cytomegalovirus infection 0 0 RAF1 1 0.12 0.27
84 hsa04714 Thermogenesis Organismal Systems Environmental adaptation FGFR1 1 0.14 0.27
85 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral PDGFRB 1 0.13 0.29


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.