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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01805


6 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04974 Protein digestion and absorption Organismal Systems Digestive system PRSS2;PRSS1 2 0.15 0.0015
2 hsa04972 Pancreatic secretion Organismal Systems Digestive system PRSS2;PRSS1 2 0.11 0.0015
3 hsa05164 Influenza A Human Diseases Infectious diseases: Viral PRSS2;PRSS1 2 0.13 0.0031
4 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction PRSS2;PRSS1 2 0.27 0.006
5 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.11 0.044
6 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.13 0.044


134 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05215 Prostate cancer Human Diseases Cancers: Specific types HSP90B1;MAPK1;PLAU 3 0.12 0.17
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system HSP90B1;GABBR1;MAPK1 3 0.12 0.23
3 hsa04659 Th17 cell differentiation Organismal Systems Immune system MAPK1 1 0.12 0.34
4 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PTPN1 1 0.11 0.34
5 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.11 0.34
6 hsa04728 Dopaminergic synapse Organismal Systems Nervous system SLC6A3 1 0.12 0.34
7 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral MAPK1 1 0.12 0.34
8 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases HSP90B1 1 0.11 0.35
9 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes MAPK1 1 0.15 0.35
10 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK1 1 0.12 0.35
11 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK1 1 0.11 0.35
12 hsa05226 Gastric cancer Human Diseases Cancers: Specific types MAPK1 1 0.11 0.35
13 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system MAPK1 1 0.11 0.35
14 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system MAPK1 1 0.12 0.35
15 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.35
16 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.13 0.35
17 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system MAPK1 1 0.11 0.35
18 hsa04726 Serotonergic synapse Organismal Systems Nervous system MAPK1 1 0.14 0.35
19 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.35
20 hsa04210 Apoptosis Cellular Processes Cell growth and death MAPK1 1 0.13 0.35
21 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.11 0.35
22 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK1 1 0.12 0.35
23 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system MAPK1 1 0.14 0.35
24 hsa05224 Breast cancer Human Diseases Cancers: Specific types MAPK1 1 0.11 0.35
25 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases SLC6A3 1 0.12 0.35
26 hsa04724 Glutamatergic synapse Organismal Systems Nervous system MAPK1 1 0.13 0.35
27 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic MAPK1 1 0.12 0.35
28 hsa04916 Melanogenesis Organismal Systems Endocrine system MAPK1 1 0.2 0.35
29 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.35
30 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system MAPK1 1 0.11 0.35
31 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death MAPK1 1 0.11 0.35
32 hsa04611 Platelet activation Organismal Systems Immune system MAPK1 1 0.11 0.35
33 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral MAPK1 1 0.11 0.35
34 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic MAPK1 1 0.12 0.35
35 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system MAPK1 1 0.12 0.35
36 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MAPK1 1 0.11 0.35
37 hsa04380 Osteoclast differentiation Organismal Systems Development MAPK1 1 0.11 0.35
38 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism MAPK1 1 0.13 0.35
39 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.36
40 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases MAPK1 1 0.11 0.36
41 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview MAPK1 1 0.18 0.36
42 hsa04218 Cellular senescence Cellular Processes Cell growth and death MAPK1 1 0.11 0.36
43 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system MAPK1 1 0.11 0.36
44 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system ALB;HSP90B1 2 0.22 0.36
45 hsa04610 Complement and coagulation cascades Organismal Systems Immune system F2;PLAU 2 0.12 0.36
46 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK1 1 0.12 0.36
47 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types MAPK1 1 0.12 0.36
48 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.36
49 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation HSP90B1 1 0.22 0.37
50 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MAPK1 1 0.11 0.37
51 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK1 1 0.12 0.37
52 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction HSP90B1;MAPK1 2 0.17 0.37
53 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PLAU 1 0.12 0.37
54 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1H 1 0.16 0.37
55 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic MAPK1 1 0.11 0.37
56 hsa04360 Axon guidance Organismal Systems Development MAPK1 1 0.17 0.37
57 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK1 1 0.15 0.37
58 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial MAPK1 1 0.11 0.37
59 hsa05200 Pathways in cancer Human Diseases Cancers: Overview HSP90B1;MAPK1 2 0.25 0.37
60 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral MAPK1 1 0.11 0.37
61 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PLAU 1 0.13 0.37
62 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system MAPK1 1 0.28 0.37
63 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CACNA1H 1 0.18 0.38
64 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1H;MAPK1 2 0.12 0.38
65 hsa04657 IL-17 signaling pathway Organismal Systems Immune system HSP90B1;MAPK1 2 0.11 0.38
66 hsa04062 Chemokine signaling pathway Organismal Systems Immune system MAPK1 1 0.12 0.38
67 hsa05032 Morphine addiction Human Diseases Substance dependence GABBR1 1 0.11 0.38
68 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNG1 1 0.13 0.38
69 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes MAPK1 1 0.11 0.38
70 hsa04727 GABAergic synapse Organismal Systems Nervous system GABBR1 1 0.13 0.38
71 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types MAPK1 1 0.14 0.39
72 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MAPK1 1 0.13 0.39
73 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes MAPK1 1 0.11 0.39
74 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview MAPK1 1 0.11 0.39
75 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.13 0.39
76 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.39
77 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.31 0.4
78 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic MAPK1 1 0.13 0.4
79 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNG1 1 0.3 0.4
80 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial MAPK1 1 0.12 0.4
81 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types MAPK1 1 0.19 0.4
82 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNG1 1 0.19 0.4
83 hsa05170 Human immunodeficiency virus 1 infection 0 0 MAPK1 1 0.11 0.4
84 hsa04742 Taste transduction Organismal Systems Sensory system GABBR1 1 0.11 0.4
85 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1;MAPK1 2 0.12 0.4
86 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types MAPK1 1 0.13 0.4
87 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic MAPK1 1 0.13 0.41
88 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic MAPK1 1 0.16 0.41
89 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNG1 1 0.31 0.41
90 hsa05163 Human cytomegalovirus infection 0 0 MAPK1 1 0.12 0.42
91 hsa05218 Melanoma Human Diseases Cancers: Specific types MAPK1 1 0.18 0.42
92 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.11 0.42
93 hsa05214 Glioma Human Diseases Cancers: Specific types MAPK1 1 0.19 0.42
94 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system MAPK1 1 0.2 0.43
95 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system MAPK1 1 0.11 0.44
96 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview MAPK1;PLAU 2 0.11 0.44
97 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types MAPK1 1 0.26 0.45
98 hsa05031 Amphetamine addiction Human Diseases Substance dependence SLC6A3 1 0.11 0.46
99 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system MAPK1 1 0.13 0.46
100 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNG1;CACNA1H;MAPK1 3 0.12 0.46
101 hsa05033 Nicotine addiction Human Diseases Substance dependence CHRNB2 1 0.13 0.46
102 hsa05219 Bladder cancer Human Diseases Cancers: Specific types MAPK1 1 0.17 0.46
103 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility F2;MAPK1 2 0.11 0.46
104 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system MAPK1 1 0.23 0.46
105 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system KLK1 1 0.14 0.47
106 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases MAPK1 1 0.13 0.47
107 hsa04720 Long-term potentiation Organismal Systems Nervous system MAPK1 1 0.13 0.47
108 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types MAPK1 1 0.21 0.47
109 hsa05030 Cocaine addiction Human Diseases Substance dependence SLC6A3 1 0.11 0.47
110 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ECI1 1 0.47 0.47
111 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types MAPK1 1 0.17 0.48
112 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types MAPK1 1 0.15 0.48
113 hsa05020 Prion diseases Human Diseases Neurodegenerative diseases MAPK1 1 0.24 0.49
114 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview MAPK1;PLAU 2 0.13 0.49
115 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview MAPK1 1 0.15 0.49
116 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK1 1 0.14 0.5
117 hsa00040 Pentose and glucuronate interconversions Metabolism Carbohydrate metabolism AKR1B1 1 0.74 0.5
118 hsa00561 Glycerolipid metabolism Metabolism Lipid metabolism AKR1B1 1 0.53 0.51
119 hsa04730 Long-term depression Organismal Systems Nervous system MAPK1 1 0.19 0.51
120 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1H 1 0.21 0.51
121 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction MAPK1 1 0.12 0.52
122 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNG1;MAPK1 2 0.11 0.52
123 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1H;MAPK1 2 0.11 0.52
124 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction GABBR1;MAPK1 2 0.18 0.53
125 hsa04614 Renin-angiotensin system Organismal Systems Endocrine system KLK1 1 0.33 0.53
126 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types MAPK1 1 0.22 0.53
127 hsa00051 Fructose and mannose metabolism Metabolism Carbohydrate metabolism AKR1B1 1 0.38 0.55
128 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral MAPK1 1 0.12 0.55
129 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins AKR1B1 1 0.3 0.55
130 hsa05034 Alcoholism Human Diseases Substance dependence SLC6A3;MAPK1 2 0.11 0.55
131 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PTPN1;MAPK1 2 0.12 0.56
132 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system CACNG1;MAPK1 2 0.11 0.56
133 hsa00052 Galactose metabolism Metabolism Carbohydrate metabolism AKR1B1 1 0.38 0.57
134 hsa01100 Metabolic pathways Metabolism Global and overview maps PRDX6;AKR1B1 2 0.27 0.82


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.