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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03359


2 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.044 0.015
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.089 0.015


101 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA1H;TNF;CACNA1I;FGFR1;CACNA1G 5 0.12 0.02
2 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1H;CACNA1I;CACNA1G 3 0.13 0.02
3 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1H;CACNA1I;CACNA1G 3 0.11 0.031
4 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1H;CACNA1I;CACNA1G 3 0.13 0.031
5 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1H;CACNA1I;CACNA1G 3 0.1 0.044
6 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF;CACNA1G 2 0.11 0.044
7 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction OPRD1;TNF;ADORA1 3 0.1 0.045
8 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases CD86;TNF 2 0.14 0.047
9 hsa05332 Graft-versus-host disease Human Diseases Immune diseases CD86;TNF 2 0.15 0.047
10 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction THRB;OPRD1;ADORA1;OPRM1 4 0.27 0.047
11 hsa05330 Allograft rejection Human Diseases Immune diseases CD86;TNF 2 0.16 0.047
12 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CACNA1H;CACNA1I;CACNA1G 3 0.19 0.064
13 hsa05032 Morphine addiction Human Diseases Substance dependence OPRM1;ADORA1 2 0.1 0.13
14 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases CD86;TNF 2 0.12 0.13
15 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system CD86;TNF 2 0.11 0.15
16 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism MIF 1 0.14 0.23
17 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases CD86;TNF 2 0.14 0.23
18 hsa00340 Histidine metabolism Metabolism Amino acid metabolism HNMT 1 0.2 0.28
19 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction OPRD1;ADORA1 2 0.13 0.28
20 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism MIF 1 0.14 0.31
21 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic TNF 1 0.14 0.31
22 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview TNF;FGFR1 2 0.13 0.31
23 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic TNF 1 0.13 0.31
24 hsa05310 Asthma Human Diseases Immune diseases TNF 1 0.24 0.31
25 hsa00051 Fructose and mannose metabolism Metabolism Carbohydrate metabolism PFKFB1 1 0.15 0.32
26 hsa00760 Nicotinate and nicotinamide metabolism Metabolism Metabolism of cofactors and vitamins NMNAT3 1 0.37 0.33
27 hsa05219 Bladder cancer Human Diseases Cancers: Specific types DAPK1 1 0.13 0.33
28 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial TNF 1 0.11 0.35
29 hsa04612 Antigen processing and presentation Organismal Systems Immune system TNF 1 0.14 0.35
30 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism CES1 1 0.13 0.35
31 hsa05218 Melanoma Human Diseases Cancers: Specific types FGFR1 1 0.13 0.35
32 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes FGFR1 1 0.11 0.35
33 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases TNF 1 0.1 0.35
34 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system FGFR1 1 0.11 0.35
35 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic TNF 1 0.11 0.35
36 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial TNF 1 0.15 0.35
37 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADORA1 1 0.1 0.35
38 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system TNF 1 0.1 0.35
39 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PFKFB1 1 0.11 0.35
40 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction TNF 1 0.11 0.35
41 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases TNF 1 0.13 0.35
42 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction TNF 1 0.14 0.35
43 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD17B1 1 0.14 0.35
44 hsa05416 Viral myocarditis Human Diseases Cardiovascular diseases CD86 1 0.18 0.35
45 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic TNF 1 0.11 0.35
46 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic TNF 1 0.11 0.36
47 hsa05320 Autoimmune thyroid disease Human Diseases Immune diseases CD86 1 0.45 0.36
48 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.13 0.36
49 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system TNF 1 0.12 0.36
50 hsa04672 Intestinal immune network for IgA production Organismal Systems Immune system CD86 1 0.29 0.36
51 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic TNF 1 0.14 0.36
52 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system TNF 1 0.11 0.36
53 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system THRB 1 0.11 0.36
54 hsa04924 Renin secretion Organismal Systems Endocrine system ADORA1 1 0.11 0.36
55 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases TNF 1 0.14 0.36
56 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases TNF 1 0.11 0.36
57 hsa05215 Prostate cancer Human Diseases Cancers: Specific types FGFR1 1 0.12 0.36
58 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system TNF 1 0.13 0.36
59 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system TNF 1 0.11 0.36
60 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases TNF 1 0.1 0.36
61 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PFKFB1 1 0.11 0.36
62 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic TNF 1 0.11 0.37
63 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview FGFR1 1 0.12 0.37
64 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases TNF 1 0.12 0.37
65 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes FGFR1 1 0.12 0.37
66 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD17B1 1 0.11 0.37
67 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases TNF 1 0.11 0.37
68 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction TNF 1 0.11 0.37
69 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral TNF 1 0.11 0.37
70 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system TNF 1 0.12 0.37
71 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral TNF 1 0.11 0.37
72 hsa04514 Cell adhesion molecules (CAMs) Environmental Information Processing Signaling molecules and interaction CD86 1 0.23 0.37
73 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases TNF 1 0.11 0.37
74 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction TNF 1 0.11 0.37
75 hsa05224 Breast cancer Human Diseases Cancers: Specific types FGFR1 1 0.1 0.37
76 hsa04657 IL-17 signaling pathway Organismal Systems Immune system TNF 1 0.1 0.37
77 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism DAPK1 1 0.11 0.37
78 hsa04380 Osteoclast differentiation Organismal Systems Development TNF 1 0.1 0.37
79 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system OPRM1 1 0.13 0.37
80 hsa04210 Apoptosis Cellular Processes Cell growth and death TNF 1 0.11 0.37
81 hsa04217 Necroptosis Cellular Processes Cell growth and death TNF 1 0.11 0.39
82 hsa05164 Influenza A Human Diseases Infectious diseases: Viral TNF 1 0.11 0.39
83 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases TNF 1 0.1 0.39
84 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.11 0.4
85 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral CD86 1 0.11 0.4
86 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview CD86 1 0.11 0.4
87 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial TNF 1 0.1 0.4
88 hsa05200 Pathways in cancer Human Diseases Cancers: Overview DAPK1;FGFR1 2 0.26 0.4
89 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral TNF 1 0.11 0.4
90 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ADORA1 1 0.19 0.41
91 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction FGFR1 1 0.12 0.42
92 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility FGFR1 1 0.12 0.42
93 hsa05170 Human immunodeficiency virus 1 infection 0 0 TNF 1 0.1 0.42
94 hsa05163 Human cytomegalovirus infection 0 0 TNF 1 0.12 0.44
95 hsa04714 Thermogenesis Organismal Systems Environmental adaptation FGFR1 1 0.11 0.44
96 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction FGFR1 1 0.11 0.44
97 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral TNF 1 0.1 0.46
98 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction TNF 1 0.11 0.51
99 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral TNF 1 0.13 0.56
100 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction FGFR1 1 0.18 0.57
101 hsa01100 Metabolic pathways Metabolism Global and overview maps NMNAT3;HSD17B1;CES1 3 0.27 0.58


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.