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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB06879


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.11 0.023
2 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NOS2 1 0.1 0.023
3 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic NOS2 1 0.12 0.023
4 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.13 0.024
5 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS2 1 0.1 0.024
6 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.15 0.025
7 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types NOS2 1 0.1 0.027
8 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NOS2 1 0.1 0.028
9 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.21 0.028
10 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NOS2 1 0.16 0.03
11 hsa04146 Peroxisome Cellular Processes Transport and catabolism NOS2 1 0.21 0.033
12 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NOS2 1 0.14 0.038
13 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.12 0.043
14 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS2 1 0.21 0.048
15 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS2 1 0.19 0.056
16 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NOS2 1 0.27 0.075
17 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS2 1 0.27 0.17


60 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;CACNA1D;CACNB2 7 0.22 9.0E-9
2 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;CACNA1D;CACNB2 7 0.41 9.0E-9
3 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;CACNA1D;CACNB2 7 0.2 9.3E-9
4 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;CACNA1D;CACNB2 7 0.15 1.1E-8
5 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;NOS3;CACNA1D;CACNB2 8 0.11 1.1E-8
6 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;CACNA1D;CACNB2 7 0.12 2.3E-7
7 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction KDR;CACNB1;CACNA1S;CACNB4;CACNA1C;CACNG1;CACNA1D;CACNB2 8 0.13 1.4E-6
8 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1C;NR0B1;CACNA1S;CACNA1D 4 0.22 0.0001
9 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction CACNA1C;NOS3;CACNA1S;SLC25A4;CACNA1D 5 0.13 0.00021
10 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1C;AHR;CACNA1S;CACNA1D 4 0.12 0.0025
11 hsa04924 Renin secretion Organismal Systems Endocrine system CACNA1C;CACNA1S;CACNA1D 3 0.13 0.0025
12 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CACNA1C;CACNA1S;NOS1;CACNA1D 4 0.13 0.0032
13 hsa04911 Insulin secretion Organismal Systems Endocrine system CACNA1C;CACNA1S;CACNA1D 3 0.14 0.0047
14 hsa04727 GABAergic synapse Organismal Systems Nervous system CACNA1C;CACNA1S;CACNA1D 3 0.16 0.0049
15 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1C;NOS1;CACNA1D 3 0.14 0.0052
16 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1C;CACNA1S;CACNA1D 3 0.19 0.0052
17 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system CACNA1C;CACNA1S;CACNA1D 3 0.15 0.0053
18 hsa04725 Cholinergic synapse Organismal Systems Nervous system CACNA1C;CACNA1S;CACNA1D 3 0.12 0.0076
19 hsa04726 Serotonergic synapse Organismal Systems Nervous system CACNA1C;CACNA1S;CACNA1D 3 0.14 0.0077
20 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system CACNA1C;CACNA1S;CACNA1D 3 0.11 0.0085
21 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CACNA1C;CACNA1S;CACNA1D 3 0.12 0.014
22 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1C;CACNA1D 2 0.17 0.015
23 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction KDR;NOS3 2 0.14 0.023
24 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CACNA1C;CACNA1S;CACNA1D 3 0.18 0.027
25 hsa05031 Amphetamine addiction Human Diseases Substance dependence CACNA1C;CACNA1D 2 0.12 0.027
26 hsa04724 Glutamatergic synapse Organismal Systems Nervous system CACNA1C;CACNA1D 2 0.15 0.07
27 hsa04728 Dopaminergic synapse Organismal Systems Nervous system CACNA1C;CACNA1D 2 0.13 0.086
28 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases KDR;NOS3 2 0.12 0.093
29 hsa00100 Steroid biosynthesis Metabolism Lipid metabolism CYP51A1 1 0.23 0.093
30 hsa04218 Cellular senescence Cellular Processes Cell growth and death SLC25A4;CACNA1D 2 0.11 0.11
31 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system CACNA1D 1 0.22 0.2
32 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system LHCGR 1 0.17 0.21
33 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases NOS1 1 0.15 0.21
34 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids ODC1 1 0.31 0.22
35 hsa04730 Long-term depression Organismal Systems Nervous system NOS1 1 0.19 0.23
36 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism SRD5A1 1 0.26 0.23
37 hsa04720 Long-term potentiation Organismal Systems Nervous system CACNA1C 1 0.16 0.24
38 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system LHCGR 1 0.12 0.25
39 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic KDR 1 0.16 0.27
40 hsa04742 Taste transduction Organismal Systems Sensory system CACNA1C 1 0.12 0.27
41 hsa04970 Salivary secretion Organismal Systems Digestive system NOS1 1 0.12 0.29
42 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NOS3 1 0.12 0.3
43 hsa00240 Pyrimidine metabolism Metabolism Nucleotide metabolism DHODH 1 0.23 0.3
44 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction KDR;NOS3 2 0.17 0.3
45 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NOS3 1 0.12 0.3
46 hsa04659 Th17 cell differentiation Organismal Systems Immune system AHR 1 0.14 0.3
47 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.13 0.32
48 hsa04611 Platelet activation Organismal Systems Immune system NOS3 1 0.11 0.32
49 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NOS3 1 0.13 0.35
50 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases SLC25A4 1 0.14 0.35
51 hsa04145 Phagosome Cellular Processes Transport and catabolism NOS1 1 0.2 0.36
52 hsa04217 Necroptosis Cellular Processes Cell growth and death SLC25A4 1 0.15 0.38
53 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes CACNA1D 1 0.19 0.38
54 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes KDR 1 0.12 0.42
55 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview KDR 1 0.13 0.42
56 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction KDR 1 0.12 0.42
57 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases SLC25A4 1 0.16 0.42
58 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction KDR 1 0.12 0.45
59 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral SLC25A4 1 0.13 0.47
60 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction LHCGR 1 0.27 0.49


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.