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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03860


5 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR2 1 0.15 0.025
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR2 1 0.15 0.025
3 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR2 1 0.15 0.031
4 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR2 1 0.2 0.033
5 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR2 1 0.25 0.07


81 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction GRIN2C;OPRM1;GRIN3A;OPRK1;GRIN2A;HRH1 6 0.27 0.0012
2 hsa05033 Nicotine addiction Human Diseases Substance dependence GRIN2A;GRIN3A;GRIN2C 3 0.18 0.0031
3 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases GRIN2A;GRIN2C;MAPK14 3 0.17 0.0032
4 hsa05030 Cocaine addiction Human Diseases Substance dependence GRIN2A;GRIN3A;GRIN2C 3 0.12 0.0032
5 hsa05031 Amphetamine addiction Human Diseases Substance dependence GRIN2A;GRIN3A;GRIN2C 3 0.12 0.006
6 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system CCNA2;PGR;MAPK14 3 0.11 0.015
7 hsa04724 Glutamatergic synapse Organismal Systems Nervous system GRIN2A;GRIN3A;GRIN2C 3 0.18 0.018
8 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;NCOA2;NCOA1 3 0.12 0.018
9 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction GRIN2A;GRIN2C;HRH1 3 0.19 0.047
10 hsa05034 Alcoholism Human Diseases Substance dependence GRIN2A;GRIN3A;GRIN2C 3 0.12 0.047
11 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases GRIN2A;MT-ATP6;GRIN2C 3 0.13 0.048
12 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction GRIN2A;GRIN3A;GRIN2C 3 0.18 0.054
13 hsa04720 Long-term potentiation Organismal Systems Nervous system GRIN2A;GRIN2C 2 0.19 0.055
14 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;MAPK14 2 0.11 0.1
15 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation GRIN2A;GRIN2C 2 0.16 0.1
16 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;AR 2 0.13 0.14
17 hsa04728 Dopaminergic synapse Organismal Systems Nervous system GRIN2A;MAPK14 2 0.12 0.15
18 hsa04218 Cellular senescence Cellular Processes Cell growth and death CCNA2;MAPK14 2 0.12 0.2
19 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction GRIN2A;MAPK14 2 0.12 0.27
20 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CCNA2;MAPK14 2 0.12 0.27
21 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;MAPK14 2 0.13 0.27
22 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism ADH1C 1 0.24 0.27
23 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MT-ATP6;MAPK14 2 0.16 0.3
24 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ADH1C 1 0.49 0.3
25 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.22 0.31
26 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system MAPK14 1 0.12 0.32
27 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CCNA2 1 0.11 0.32
28 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases GRIN2A 1 0.35 0.32
29 hsa00190 Oxidative phosphorylation Metabolism Energy metabolism MT-ATP6 1 0.36 0.32
30 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system MAPK14 1 0.11 0.32
31 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes MAPK14 1 0.26 0.32
32 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases MAPK14 1 0.12 0.32
33 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.15 0.32
34 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.33
35 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral MAPK14 1 0.14 0.33
36 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MAPK14 1 0.12 0.33
37 hsa04611 Platelet activation Organismal Systems Immune system MAPK14 1 0.12 0.33
38 hsa04110 Cell cycle Cellular Processes Cell growth and death CCNA2 1 0.16 0.33
39 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction CCNA2 1 0.15 0.34
40 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK14 1 0.16 0.34
41 hsa04380 Osteoclast differentiation Organismal Systems Development MAPK14 1 0.12 0.34
42 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic MAPK14 1 0.16 0.34
43 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system MAPK14 1 0.3 0.34
44 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.16 0.34
45 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.13 0.34
46 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism ADH1C 1 0.34 0.34
47 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.16 0.34
48 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.13 0.34
49 hsa04659 Th17 cell differentiation Organismal Systems Immune system MAPK14 1 0.14 0.34
50 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.15 0.34
51 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic MAPK14 1 0.13 0.35
52 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.17 0.35
53 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic MAPK14 1 0.16 0.35
54 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK14 1 0.16 0.35
55 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MAPK14 1 0.12 0.35
56 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism ADH1C 1 0.27 0.35
57 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases MAPK14 1 0.12 0.35
58 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.24 0.35
59 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.14 0.35
60 hsa05164 Influenza A Human Diseases Infectious diseases: Viral MAPK14 1 0.12 0.35
61 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.12 0.35
62 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.2 0.35
63 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview ADH1C 1 0.22 0.35
64 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system MAPK14 1 0.17 0.36
65 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK14 1 0.25 0.36
66 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.21 0.36
67 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.12 0.36
68 hsa05032 Morphine addiction Human Diseases Substance dependence OPRM1 1 0.12 0.36
69 hsa00010 Glycolysis / Gluconeogenesis Metabolism Carbohydrate metabolism ADH1C 1 0.37 0.37
70 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.37
71 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.14 0.37
72 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.2 0.37
73 hsa00830 Retinol metabolism Metabolism Metabolism of cofactors and vitamins ADH1C 1 0.36 0.38
74 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CCNA2 1 0.12 0.38
75 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.23 0.39
76 hsa05170 Human immunodeficiency virus 1 infection 0 0 MAPK14 1 0.13 0.39
77 hsa05163 Human cytomegalovirus infection 0 0 MAPK14 1 0.12 0.41
78 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction GRIN2A 1 0.11 0.41
79 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.49
80 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral CCNA2 1 0.13 0.53
81 hsa01100 Metabolic pathways Metabolism Global and overview maps MT-ATP6;ADH1C 2 0.27 0.79


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.