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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07691


4 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARD 1 0.068 0.02
2 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.053 0.02
3 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.053 0.026
4 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARD 1 0.25 0.07


154 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types RXRB;RXRG;PPARG;MAPK3;RXRA 5 0.15 1.0E-6
2 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA;RXRB;ACSL4;RXRA;RXRG 5 0.13 1.2E-5
3 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRB;CYP24A1;RXRA;MAPK3;RXRG 5 0.11 7.2E-5
4 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types RXRB;RXRA;MAPK3;RXRG 4 0.14 0.00027
5 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRB;RXRA;MAPK3;RXRG 4 0.11 0.0015
6 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system RXRB;RXRA;MAPK3;RXRG 4 0.11 0.0017
7 hsa05226 Gastric cancer Human Diseases Cancers: Specific types RXRB;RXRA;MAPK3;RXRG 4 0.1 0.0038
8 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview RXRB;RXRG;PPARG;RXRA 4 0.12 0.0079
9 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types RXRB;RXRA;RXRG 3 0.1 0.013
10 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA;RXRA;MAPK3 3 0.11 0.03
11 hsa05020 Prion diseases Human Diseases Neurodegenerative diseases C5;MAPK3 2 0.15 0.03
12 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system SLC8A1;ADRB2;MAPK3 3 0.11 0.035
13 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction SLC8A1;ADRB2;MAPK3 3 0.12 0.045
14 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB2;PTGS1 2 0.1 0.056
15 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA;ADRB2;MAPK3 3 0.18 0.066
16 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PLA2G1B;PTGS1 2 0.11 0.066
17 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial C5;MAPK3 2 0.11 0.089
18 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR;MAPK3 2 0.1 0.14
19 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG;MAPK3 2 0.1 0.17
20 hsa00061 Fatty acid biosynthesis Metabolism Lipid metabolism ACSL4 1 0.2 0.17
21 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;MAPK3 2 0.1 0.17
22 hsa04611 Platelet activation Organismal Systems Immune system MAPK3;PTGS1 2 0.1 0.17
23 hsa04726 Serotonergic synapse Organismal Systems Nervous system MAPK3;PTGS1 2 0.14 0.18
24 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction SLC8A1;MAPK3 2 0.11 0.18
25 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system PGR;MAPK3 2 0.12 0.18
26 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G1B;MAPK3 2 0.1 0.18
27 hsa05224 Breast cancer Human Diseases Cancers: Specific types PGR;MAPK3 2 0.1 0.19
28 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA;RXRA 2 0.11 0.19
29 hsa00100 Steroid biosynthesis Metabolism Lipid metabolism CYP24A1 1 0.2 0.2
30 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.2 0.25
31 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction SLC8A1;ADRB2 2 0.18 0.25
32 hsa00053 Ascorbate and aldarate metabolism Metabolism Carbohydrate metabolism UGT1A9 1 0.2 0.25
33 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.15 0.26
34 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK3 1 0.11 0.27
35 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK3 1 0.1 0.27
36 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.11 0.27
37 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic MAPK3 1 0.11 0.27
38 hsa04916 Melanogenesis Organismal Systems Endocrine system MAPK3 1 0.14 0.27
39 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system MAPK3 1 0.11 0.27
40 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA 1 0.1 0.28
41 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.28
42 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases MAPK3 1 0.1 0.28
43 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview MAPK3 1 0.14 0.28
44 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.28
45 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic MAPK3 1 0.1 0.28
46 hsa05215 Prostate cancer Human Diseases Cancers: Specific types MAPK3 1 0.12 0.28
47 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.15 0.28
48 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK3 1 0.11 0.28
49 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MAPK3 1 0.1 0.28
50 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic MAPK3 1 0.11 0.28
51 hsa04724 Glutamatergic synapse Organismal Systems Nervous system MAPK3 1 0.11 0.28
52 hsa04725 Cholinergic synapse Organismal Systems Nervous system MAPK3 1 0.1 0.28
53 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G1B 1 0.11 0.28
54 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation MAPK3 1 0.11 0.28
55 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK3 1 0.12 0.28
56 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system MAPK3 1 0.15 0.28
57 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases SLC8A1 1 0.11 0.28
58 hsa04974 Protein digestion and absorption Organismal Systems Digestive system SLC8A1 1 0.11 0.28
59 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.11 0.29
60 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK3 1 0.11 0.29
61 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.29
62 hsa04970 Salivary secretion Organismal Systems Digestive system ADRB2 1 0.1 0.29
63 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types MAPK3 1 0.12 0.29
64 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MAPK3 1 0.11 0.29
65 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.12 0.29
66 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes MAPK3 1 0.11 0.29
67 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.29
68 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction RXRA;MAPK3 2 0.17 0.29
69 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.16 0.29
70 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism UGT1A9 1 0.15 0.3
71 hsa04610 Complement and coagulation cascades Organismal Systems Immune system C5 1 0.11 0.3
72 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases SLC8A1 1 0.14 0.3
73 hsa04146 Peroxisome Cellular Processes Transport and catabolism ACSL4 1 0.15 0.3
74 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic MAPK3 1 0.12 0.3
75 hsa00040 Pentose and glucuronate interconversions Metabolism Carbohydrate metabolism UGT1A9 1 0.21 0.3
76 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism UGT1A9 1 0.14 0.3
77 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types MAPK3 1 0.14 0.3
78 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism MAPK3 1 0.11 0.3
79 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.1 0.3
80 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases C5 1 0.15 0.3
81 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview UGT1A9 1 0.12 0.3
82 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system MAPK3 1 0.12 0.3
83 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MAPK3 1 0.11 0.3
84 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system SLC8A1 1 0.16 0.3
85 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system MAPK3 1 0.11 0.3
86 hsa04210 Apoptosis Cellular Processes Cell growth and death MAPK3 1 0.12 0.3
87 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types MAPK3 1 0.11 0.3
88 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G1B 1 0.14 0.3
89 hsa00860 Porphyrin and chlorophyll metabolism Metabolism Metabolism of cofactors and vitamins UGT1A9 1 0.21 0.3
90 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic MAPK3 1 0.12 0.3
91 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes MAPK3 1 0.13 0.31
92 hsa05219 Bladder cancer Human Diseases Cancers: Specific types MAPK3 1 0.14 0.31
93 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic MAPK3 1 0.13 0.31
94 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases SLC8A1 1 0.16 0.31
95 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes MAPK3 1 0.11 0.31
96 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system SLC8A1 1 0.12 0.31
97 hsa01212 Fatty acid metabolism Metabolism Global and overview maps ACSL4 1 0.25 0.31
98 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.18 0.31
99 hsa05218 Melanoma Human Diseases Cancers: Specific types MAPK3 1 0.14 0.31
100 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ACSL4 1 0.17 0.31
101 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral MAPK3 1 0.1 0.31
102 hsa04216 Ferroptosis Cellular Processes Cell growth and death ACSL4 1 0.18 0.31
103 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.31
104 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLA2G1B;MAPK3 2 0.11 0.31
105 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system MAPK3 1 0.1 0.31
106 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism UGT1A9 1 0.15 0.32
107 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system MAPK3 1 0.14 0.32
108 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases MAPK3 1 0.12 0.32
109 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system MAPK3 1 0.1 0.32
110 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.32
111 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases MAPK3 1 0.1 0.32
112 hsa04978 Mineral absorption Organismal Systems Digestive system SLC8A1 1 0.14 0.32
113 hsa04976 Bile secretion Organismal Systems Digestive system RXRA 1 0.11 0.32
114 hsa05214 Glioma Human Diseases Cancers: Specific types MAPK3 1 0.14 0.32
115 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ACSL4;PPARG 2 0.11 0.32
116 hsa04218 Cellular senescence Cellular Processes Cell growth and death MAPK3 1 0.1 0.33
117 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system MAPK3 1 0.14 0.33
118 hsa01100 Metabolic pathways Metabolism Global and overview maps UGT1A9;ACSL4;PLA2G1B;CYP24A1;PTGS1 5 0.27 0.33
119 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism UGT1A9 1 0.17 0.33
120 hsa04730 Long-term depression Organismal Systems Nervous system MAPK3 1 0.14 0.33
121 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system MAPK3 1 0.1 0.33
122 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.33
123 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types MAPK3 1 0.15 0.33
124 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system MAPK3 1 0.11 0.33
125 hsa00830 Retinol metabolism Metabolism Metabolism of cofactors and vitamins UGT1A9 1 0.16 0.33
126 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK3 1 0.11 0.33
127 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types MAPK3 1 0.11 0.33
128 hsa05164 Influenza A Human Diseases Infectious diseases: Viral MAPK3 1 0.11 0.34
129 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MAPK3 1 0.1 0.34
130 hsa05150 Staphylococcus aureus infection Human Diseases Infectious diseases: Bacterial C5 1 0.15 0.34
131 hsa04720 Long-term potentiation Organismal Systems Nervous system MAPK3 1 0.11 0.34
132 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK3 1 0.13 0.34
133 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB2 1 0.11 0.34
134 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types MAPK3 1 0.15 0.34
135 hsa04360 Axon guidance Organismal Systems Development MAPK3 1 0.14 0.34
136 hsa05034 Alcoholism Human Diseases Substance dependence MAPK3 1 0.1 0.34
137 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial MAPK3 1 0.1 0.34
138 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview MAPK3 1 0.12 0.34
139 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral MAPK3 1 0.1 0.35
140 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral C5 1 0.11 0.35
141 hsa04062 Chemokine signaling pathway Organismal Systems Immune system MAPK3 1 0.11 0.35
142 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.11 0.35
143 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview MAPK3 1 0.12 0.36
144 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview MAPK3 1 0.1 0.36
145 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes MAPK3 1 0.1 0.36
146 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.11 0.36
147 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility MAPK3 1 0.11 0.37
148 hsa05170 Human immunodeficiency virus 1 infection 0 0 MAPK3 1 0.1 0.37
149 hsa05163 Human cytomegalovirus infection 0 0 MAPK3 1 0.11 0.38
150 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRB2 1 0.27 0.44
151 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction MAPK3 1 0.12 0.46
152 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP24A1 1 0.1 0.46
153 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral MAPK3 1 0.12 0.51
154 hsa04740 Olfactory transduction Organismal Systems Sensory system SLC8A1 1 0.15 0.6


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.