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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB12200


20 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic MET 1 0.12 0.026
2 hsa05100 Bacterial invasion of epithelial cells Human Diseases Infectious diseases: Bacterial MET 1 0.25 0.026
3 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes MET 1 0.11 0.028
4 hsa05218 Melanoma Human Diseases Cancers: Specific types MET 1 0.15 0.032
5 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview MET 1 0.13 0.037
6 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction MET 1 0.13 0.037
7 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes MET 1 0.12 0.038
8 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types MET 1 0.18 0.039
9 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction MET 1 0.12 0.039
10 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MET 1 0.12 0.041
11 hsa04360 Axon guidance Organismal Systems Development MET 1 0.13 0.041
12 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types MET 1 0.11 0.043
13 hsa05226 Gastric cancer Human Diseases Cancers: Specific types MET 1 0.12 0.044
14 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction MET 1 0.13 0.044
15 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview MET 1 0.12 0.044
16 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MET 1 0.12 0.046
17 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction MET 1 0.18 0.05
18 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview MET 1 0.13 0.061
19 hsa05200 Pathways in cancer Human Diseases Cancers: Overview MET 1 0.25 0.07
20 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic MET 1 0.18 0.087


72 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types ALK;EGFR;ERBB2 3 0.15 0.03
2 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system HSP90AA1;PGR;CDK1 3 0.11 0.032
3 hsa05215 Prostate cancer Human Diseases Cancers: Specific types HSP90AA1;EGFR;ERBB2 3 0.12 0.032
4 hsa05224 Breast cancer Human Diseases Cancers: Specific types PGR;EGFR;ERBB2 3 0.11 0.05
5 hsa05219 Bladder cancer Human Diseases Cancers: Specific types EGFR;ERBB2 2 0.15 0.05
6 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system HSP90AA1;PGR;EGFR 3 0.13 0.055
7 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types EGFR;ERBB2 2 0.17 0.077
8 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism ALOX5;PLA2G1B 2 0.12 0.079
9 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types EGFR;ERBB2 2 0.13 0.098
10 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes CDK1;EGFR 2 0.11 0.11
11 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction EGFR;ERBB2 2 0.13 0.11
12 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction EGFR;ERBB2 2 0.11 0.12
13 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic EGFR;ERBB2 2 0.11 0.12
14 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CNR1;NR3C1;OPRK1 3 0.27 0.12
15 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;CDK1 2 0.11 0.15
16 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction PIM1;EGFR 2 0.12 0.23
17 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.24 0.23
18 hsa00030 Pentose phosphate pathway Metabolism Carbohydrate metabolism PGD 1 0.36 0.24
19 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.17 0.24
20 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction EGFR;ERBB2 2 0.19 0.24
21 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic HBB 1 0.18 0.26
22 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G1B 1 0.17 0.29
23 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCB1 1 0.18 0.3
24 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5 1 0.13 0.31
25 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.19 0.31
26 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids PGD 1 0.17 0.33
27 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CDK1 1 0.13 0.35
28 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic ERBB2 1 0.14 0.35
29 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview EGFR 1 0.16 0.35
30 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases PIM1 1 0.11 0.35
31 hsa04610 Complement and coagulation cascades Organismal Systems Immune system F10 1 0.13 0.35
32 hsa04612 Antigen processing and presentation Organismal Systems Immune system HSP90AA1 1 0.18 0.35
33 hsa05214 Glioma Human Diseases Cancers: Specific types EGFR 1 0.16 0.35
34 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system EGFR 1 0.12 0.36
35 hsa04659 Th17 cell differentiation Organismal Systems Immune system HSP90AA1 1 0.12 0.36
36 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.17 0.36
37 hsa01200 Carbon metabolism Metabolism Global and overview maps PGD 1 0.17 0.36
38 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5 1 0.14 0.36
39 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G1B 1 0.11 0.36
40 hsa04976 Bile secretion Organismal Systems Digestive system ABCB1 1 0.12 0.36
41 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction EGFR 1 0.11 0.36
42 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral EGFR 1 0.12 0.36
43 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.12 0.36
44 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system EGFR 1 0.12 0.36
45 hsa04657 IL-17 signaling pathway Organismal Systems Immune system HSP90AA1 1 0.11 0.36
46 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G1B 1 0.11 0.36
47 hsa04110 Cell cycle Cellular Processes Cell growth and death CDK1 1 0.12 0.36
48 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system EGFR 1 0.11 0.37
49 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types EGFR 1 0.14 0.37
50 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PIM1 1 0.14 0.37
51 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.12 0.37
52 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases HSP90AA1 1 0.11 0.37
53 hsa04974 Protein digestion and absorption Organismal Systems Digestive system DPP4 1 0.12 0.37
54 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes ERBB2 1 0.13 0.38
55 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system HSP90AA1 1 0.12 0.38
56 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases EGFR 1 0.11 0.38
57 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system EGFR 1 0.11 0.38
58 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CNR1 1 0.11 0.38
59 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction EGFR 1 0.12 0.38
60 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation HSP90AA1 1 0.19 0.38
61 hsa04217 Necroptosis Cellular Processes Cell growth and death HSP90AA1 1 0.12 0.38
62 hsa04218 Cellular senescence Cellular Processes Cell growth and death CDK1 1 0.11 0.38
63 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CDK1 1 0.11 0.4
64 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CDK1 1 0.11 0.41
65 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CDK1 1 0.11 0.41
66 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility EGFR 1 0.11 0.42
67 hsa05170 Human immunodeficiency virus 1 infection 0 0 CDK1 1 0.11 0.42
68 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CNR1 1 0.13 0.43
69 hsa05163 Human cytomegalovirus infection 0 0 EGFR 1 0.11 0.43
70 hsa04144 Endocytosis Cellular Processes Transport and catabolism EGFR 1 0.16 0.44
71 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral EGFR 1 0.13 0.55
72 hsa01100 Metabolic pathways Metabolism Global and overview maps ALOX5;PLA2G1B;PGD 3 0.27 0.58


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.