QuartataWeb
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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB12200


20 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic MET 1 0.12 0.026
2 hsa05100 Bacterial invasion of epithelial cells Human Diseases Infectious diseases: Bacterial MET 1 0.25 0.026
3 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes MET 1 0.11 0.028
4 hsa05218 Melanoma Human Diseases Cancers: Specific types MET 1 0.15 0.032
5 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview MET 1 0.13 0.037
6 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction MET 1 0.13 0.037
7 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes MET 1 0.12 0.038
8 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types MET 1 0.18 0.039
9 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction MET 1 0.12 0.039
10 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MET 1 0.12 0.041
11 hsa04360 Axon guidance Organismal Systems Development MET 1 0.13 0.041
12 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types MET 1 0.11 0.043
13 hsa05226 Gastric cancer Human Diseases Cancers: Specific types MET 1 0.12 0.044
14 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction MET 1 0.13 0.044
15 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview MET 1 0.12 0.044
16 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MET 1 0.12 0.046
17 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction MET 1 0.18 0.05
18 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview MET 1 0.13 0.061
19 hsa05200 Pathways in cancer Human Diseases Cancers: Overview MET 1 0.25 0.07
20 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic MET 1 0.18 0.087


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.