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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB02911


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NOS3 1 0.14 0.026
2 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NOS3 1 0.14 0.026
3 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system NOS3 1 0.14 0.026
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.14 0.026
5 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.19 0.028
6 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.29 0.028
7 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS3 1 0.13 0.031
8 hsa04611 Platelet activation Organismal Systems Immune system NOS3 1 0.13 0.033
9 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.18 0.035
10 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NOS3 1 0.15 0.038
11 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.2 0.041
12 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS3 1 0.32 0.045
13 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.23 0.045
14 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NOS3 1 0.16 0.046
15 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS3 1 0.34 0.048
16 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.19 0.05
17 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS3 1 0.27 0.17


89 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRM5;CHRM2;CHRM4;TRPV1;ADRB1;CHRM1;HTR2A;CHRM3 8 0.27 5.2E-6
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.11 0.00017
3 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.11 0.0025
4 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NOS2;TLR4;NFKB1 3 0.14 0.011
5 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic NOS2;TLR4;NFKB1 3 0.14 0.011
6 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NOS2;TLR4;NFKB1 3 0.15 0.011
7 hsa04970 Salivary secretion Organismal Systems Digestive system ADRB1;CHRM3;NOS1 3 0.11 0.011
8 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ADRB1;CHRM2;CHRM1;NFKB1 4 0.18 0.011
9 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NOS2;TLR4;NFKB1 3 0.15 0.012
10 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NOS2;TLR4;NFKB1 3 0.12 0.013
11 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic NOS2;TLR4;NFKB1 3 0.13 0.016
12 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NOS2;TLR4;NFKB1 3 0.11 0.049
13 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial TLR4;NFKB1 2 0.22 0.049
14 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases TLR4;NFKB1 2 0.23 0.059
15 hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis Metabolism Amino acid metabolism PAH 1 0.36 0.067
16 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system TRPV1;HTR2A 2 0.11 0.08
17 hsa05215 Prostate cancer Human Diseases Cancers: Specific types MMP3;NFKB1 2 0.12 0.08
18 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction TLR4;NFKB1 2 0.14 0.081
19 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MMP3;NFKB1 2 0.11 0.081
20 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types NOS2;NFKB1 2 0.11 0.082
21 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;CHRM3 2 0.11 0.083
22 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system TLR4;NFKB1 2 0.14 0.085
23 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes ADRB1;HTR2A 2 0.11 0.086
24 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases MMP3;TLR4 2 0.17 0.086
25 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MMP3;NFKB1 2 0.13 0.09
26 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;HTR2A 2 0.14 0.094
27 hsa05162 Measles Human Diseases Infectious diseases: Viral TLR4;NFKB1 2 0.11 0.12
28 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism PAH 1 0.36 0.12
29 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral TLR4;NFKB1 2 0.11 0.13
30 hsa04145 Phagosome Cellular Processes Transport and catabolism TLR4;NOS1 2 0.19 0.14
31 hsa05164 Influenza A Human Diseases Infectious diseases: Viral TLR4;NFKB1 2 0.11 0.16
32 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins PAH 1 0.26 0.16
33 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TLR4;NFKB1 2 0.13 0.16
34 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MMP3;NFKB1 2 0.13 0.17
35 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic NFKB1 1 0.2 0.17
36 hsa05170 Human immunodeficiency virus 1 infection 0 0 TLR4;NFKB1 2 0.12 0.2
37 hsa05030 Cocaine addiction Human Diseases Substance dependence NFKB1 1 0.11 0.25
38 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic TLR4 1 0.22 0.25
39 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases NOS1 1 0.15 0.25
40 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types NFKB1 1 0.19 0.25
41 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps PAH 1 0.23 0.25
42 hsa05130 Pathogenic Escherichia coli infection Human Diseases Infectious diseases: Bacterial TLR4 1 0.38 0.25
43 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids ODC1 1 0.33 0.25
44 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3 1 0.14 0.26
45 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB1 1 0.11 0.26
46 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.19 0.26
47 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system NFKB1 1 0.11 0.26
48 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.21 0.26
49 hsa04610 Complement and coagulation cascades Organismal Systems Immune system A2M 1 0.13 0.26
50 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types NFKB1 1 0.15 0.26
51 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system NFKB1 1 0.18 0.26
52 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial NFKB1 1 0.15 0.27
53 hsa04730 Long-term depression Organismal Systems Nervous system NOS1 1 0.19 0.27
54 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types NFKB1 1 0.16 0.27
55 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial NFKB1 1 0.16 0.27
56 hsa04146 Peroxisome Cellular Processes Transport and catabolism NOS2 1 0.28 0.27
57 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.14 0.27
58 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB1 1 0.12 0.27
59 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system NFKB1 1 0.51 0.27
60 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ADRB1 1 0.15 0.27
61 hsa04211 Longevity regulating pathway Organismal Systems Aging NFKB1 1 0.15 0.27
62 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system NFKB1 1 0.18 0.27
63 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation NOS1 1 0.14 0.27
64 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.11 0.27
65 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.15 0.28
66 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.11 0.29
67 hsa04659 Th17 cell differentiation Organismal Systems Immune system NFKB1 1 0.12 0.29
68 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system NFKB1 1 0.14 0.31
69 hsa04380 Osteoclast differentiation Organismal Systems Development NFKB1 1 0.11 0.33
70 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral NFKB1 1 0.12 0.33
71 hsa04210 Apoptosis Cellular Processes Cell growth and death NFKB1 1 0.14 0.34
72 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRB1 1 0.11 0.35
73 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases NFKB1 1 0.13 0.35
74 hsa04217 Necroptosis Cellular Processes Cell growth and death TLR4 1 0.13 0.37
75 hsa04218 Cellular senescence Cellular Processes Cell growth and death NFKB1 1 0.11 0.37
76 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases NOS1 1 0.11 0.38
77 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NOS2;NFKB1 2 0.25 0.39
78 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.39
79 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral NFKB1 1 0.12 0.39
80 hsa04062 Chemokine signaling pathway Organismal Systems Immune system NFKB1 1 0.13 0.39
81 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview NFKB1 1 0.11 0.4
82 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.4
83 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview TLR4 1 0.13 0.4
84 hsa05163 Human cytomegalovirus infection 0 0 NFKB1 1 0.11 0.43
85 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction NFKB1 1 0.11 0.44
86 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.46
87 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview NFKB1 1 0.11 0.51
88 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction NFKB1 1 0.12 0.51
89 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral NFKB1 1 0.12 0.55


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.